Secondary hyperparathyroidism: Predictors and relationship with vitamin D status, bone turnover markers and bone mineral density

Donal Fitzpatrick; Eamon Laird; Mary Ward; Leane Hoey; Catherine F Hughes; J J Strain; Conal Cunningham; Martin Healy; Anne M Molloy; Helene McNulty; Rosaleen Lannon; Kevin McCarroll

doi:10.1016/j.bone.2024.117108

Secondary hyperparathyroidism: Predictors and relationship with vitamin D status, bone turnover markers and bone mineral density

Donal Fitzpatrick, Eamon Laird, Mary Ward, Leane Hoey, Catherine F Hughes, J J Strain, Conal Cunningham, Martin Healy, Anne M Molloy, Helene McNulty, Rosaleen Lannon, Kevin McCarroll

Faculty Of Life & Health Sciences

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Abstract

Secondary hyperparathyroidism (SHPT) has adverse implications for bone health but is relatively understudied. In this study we examine the prevalence and determinants of SHPT and describe the relationship of SHPT with bone turnover markers and bone mineral density (BMD) in older Irish adults. Eligible participants (n = 4139) were identified from the Trinity-Ulster-Department of Agriculture (TUDA) study, a cohort of Irish adults aged ≥60 years. Exclusion criteria included an estimated glomerular filtration rate (eGFR) 2.5 mmol/l to remove hyperparathyroidism due to advanced chronic kidney disease (CKD) and primary hyperparathyroidism respectively. The relationship between SHPT and bone turnover markers and BMD (measured by densitometry) was examined in a subsample (n = 1488). Vitamin D deficiency was defined as 25-hydroxyvitamin D [25 (OH)D]

Original language	English
Article number	117108
Pages (from-to)	1-10
Number of pages	10
Journal	Bone
Volume	184
Early online date	18 Apr 2024
DOIs	https://doi.org/10.1016/j.bone.2024.117108
Publication status	Published (in print/issue) - 1 Jul 2024

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Publisher Copyright:
© 2024

Keywords

Calcium supplementation
Markers
Secondary hyperparathyroidism
Vitamin D
Parathyroid hormone
Bone turnover
Bone mineral density

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bone.2024.117108

1-s2.0-S8756328224000978-mainFinal published version, 883 KBLicence: CC BY

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Fitzpatrick, D., Laird, E., Ward, M., Hoey, L., Hughes, C. F., Strain, J. J., Cunningham, C., Healy, M., Molloy, A. M., McNulty, H., Lannon, R., & McCarroll, K. (2024). Secondary hyperparathyroidism: Predictors and relationship with vitamin D status, bone turnover markers and bone mineral density. Bone, 184, 1-10. Article 117108. https://doi.org/10.1016/j.bone.2024.117108

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AU - Strain, J J

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Secondary hyperparathyroidism: Predictors and relationship with vitamin D status, bone turnover markers and bone mineral density

Abstract

Bibliographical note

Keywords

UN SDGs

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