SARS‐CoV‐2 research using human pluripotent stem cells and organoids

Sayaka Deguchi, Ángel Serrano‐aroca, Murtaza M. Tambuwala, Bruce D. Uhal, Adam M. Brufsky, Kazuo Takayama

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)
43 Downloads (Pure)

Abstract

Experimental cell models are indispensable for clarifying the pathophysiology of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and for developing therapeutic agents. To recapitulate the symptoms and drug response of COVID-19 patients in vitro, SARS-CoV-2 studies using physiologically relevant human embryonic stem (ES)/induced pluripotent stem (iPS) cell-derived somatic cells and organoids are ongoing. These cells and organoids have been used to show that SARS-CoV-2 can infect and damage various organs including the lung, heart, brain, intestinal tract, kidney, and pancreas. They are also being used to develop COVID-19 therapeutic agents, including evaluation of their antiviral efficacy and safety. The relationship between COVID-19 aggravation and human genetic backgrounds has been investigated using genetically modified ES/iPS cells and patient-derived iPS cells. This review summarizes the latest results and issues of SARS-CoV-2 research using human ES/iPS cell-derived somatic cells and organoids.
Original languageEnglish
Pages (from-to)1491-1499
Number of pages9
JournalSTEM CELLS Translational Medicine
Volume10
Issue number11
DOIs
Publication statusPublished (in print/issue) - 24 Jul 2021

Bibliographical note

Funding Information:
We thank Dr. Peter Karagiannis (Kyoto University) for critical reading of the manuscript and Dr. Misaki Ouchida (Kyoto University) for drawing the graphical abstract.

Publisher Copyright:
© 2021 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press.

Keywords

  • COVID-19
  • SARS-CoV-2
  • human ES cells
  • human iPS cells
  • organoids

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