SARS-CoV-2 and Coronavirus Disease Mitigation: Treatment Options, Vaccinations and Variants

Almu’atasim Khamees, Jamal Bani-issa, Mazhar Salim Al Zoubi, Taqwa Qasem, Manal Issam Abualarjah, Sura Ahmad Alawadin, Khayry Al-shami, Farah E. Hussein, Emad Hussein, Ibrahim H. Bashayreh, Murtaza M. Tambuwala, Mohannad Al-saghir, Christopher T. Cornelison

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)
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COVID-19 is caused by a novel coronavirus (2019-nCoV), which was declared as a pandemic after it emerged in China 2019. A vast international effort has been conducted to prevent and treat COVID-19 due to its high transmissibility and severe morbidity and mortality rates, particularly in individuals with chronic co-morbidities. In addition, polymorphic variants increased the need for proper vaccination to overcome the infectivity of new variants that are emerging across the globe. Many treatment options have been proposed and more than 25 vaccines are in various stages of development; however, the infection peaks are oscillating periodically, which raises a significant question about the effectiveness of the prevention measures and the persistence of this pandemic disease. In this review, we are exploring the most recent knowledge and advances in the treatment and vaccination options as well as the new emerging variants of 2019-nCoV and the possible mitigation of one of the most aggressive pandemics in the last centuries.
Original languageEnglish
Article number275
Pages (from-to)1-38
Number of pages38
Issue number2
Publication statusPublished (in print/issue) - 20 Feb 2022

Bibliographical note

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© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • vaccines
  • pandemic
  • COVID-19
  • variants
  • Pandemic
  • 2019-nCoV


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