Salmonella enterica var Typhimurium and Salmonella enterica var Enteritidis express type 1 fimbriae in the rat in vivo

SWB Ewen, Patrick Naughton, G Grant, M Sojka, E AllenVercoe, S Bardocz, CJ Thorns, A Pusztai

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In a series of experiments rats were dosed with purified type 1 fimbriae from Salmonella enterica var Enteritidis or with fimbriated cultures of either S. enterica var Typhimurium or S. enterica var Enteritidis, Paraffin-wax embedded histological sections of jejunal and ileal tissue were taken and stained by the streptavidin biotin complex (sABC) staining technique for the detection of salmonella and type 1 fimbriae. On oral infection with Enteritidis and Typhimurium both bacteria were shown to be closely associated with the rat ileal epithelium and expressed type 1 fimbriae, thus clearly demonstrating that type 1 fimbriae are expressed by salmonellae in vivo. Moreover, association with the ileum was also shown to occur when purified type 1 fimbriae were orally administered to rats. Our results suggest that type 1 fimbriae alone or in combination with other fimbriae may play an important role in the early stages of infection with these pathogenic bacteria.
Original languageEnglish
Pages (from-to)185-192
JournalFEMS Immunology and Medical Microbiology
Volume18
Issue number3
Publication statusPublished - Jul 1997

Keywords

  • Rat model
  • Salmonella
  • Type 1 fimbriae

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