Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches

Ashleigh Anderson; Aaron McConville; Laura Fanthorpe; James Davis

doi:10.3390/medicines4030048

Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches

Ashleigh Anderson
, Aaron McConville
, Laura Fanthorpe
, James Davis

Department of Employment and Learning (DEL)

Research output: Contribution to journal › Article › peer-review

131 Downloads (Pure)

Abstract

The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse.

Original language	English
Pages (from-to)	48
Journal	Medicines
Volume	4
Issue number	3
DOIs	https://doi.org/10.3390/medicines4030048
Publication status	Published (in print/issue) - 30 Jun 2017

Keywords

smart patches
methyl salicylate
toxicity
microneedle
transdermal

Access to Document

10.3390/medicines4030048

Medicines-04-00048Final published version, 1.29 MB

Smart patch systems for controlled drug delivery and sensing applications
McConville, A. (Author), Davis, J. (Supervisor) & Papakonstantinou, P. (Supervisor), May 2019
Student thesis: Doctoral Thesis

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Tunable nanomaterials for controlled drug release in smart devices
Anderson, A. (Author), Davis, J. (Supervisor) & Papakonstantinou, P. (Supervisor), Sept 2018
Student thesis: Doctoral Thesis

File

Cite this

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title = "Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches",

abstract = "The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse.",

keywords = "smart patches, methyl salicylate, toxicity, microneedle, transdermal",

author = "Ashleigh Anderson and Aaron McConville and Laura Fanthorpe and James Davis",

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day = "30",

doi = "10.3390/medicines4030048",

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T1 - Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches

AU - Anderson, Ashleigh

AU - McConville, Aaron

AU - Fanthorpe, Laura

AU - Davis, James

PY - 2017/6/30

Y1 - 2017/6/30

N2 - The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse.

AB - The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse.

KW - smart patches

KW - methyl salicylate

KW - toxicity

KW - microneedle

KW - transdermal

U2 - 10.3390/medicines4030048

DO - 10.3390/medicines4030048

M3 - Article

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SN - 2305-6320

VL - 4

SP - 48

JO - Medicines

JF - Medicines

IS - 3

ER -

Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches

Abstract

Keywords

Access to Document

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Student theses

Smart patch systems for controlled drug delivery and sensing applications

Tunable nanomaterials for controlled drug release in smart devices

Cite this