Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches

Ashleigh Anderson, Aaron McConville, Laura Fanthorpe, James Davis

Research output: Contribution to journalArticle

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Abstract

The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse.
Original languageEnglish
Pages (from-to)48
JournalMedicines
Volume4
Issue number3
DOIs
Publication statusPublished - 30 Jun 2017

Keywords

  • smart patches
  • methyl salicylate
  • toxicity
  • microneedle
  • transdermal

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