Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events

Melody El Chemaly; V. E. McGilligan; Mark Gibson; Matthias  Clauss; Steven Watterson; H. Denis Alexander; AJ Bjourson; Aaron Peace

doi:10.1016/j.acvd.2017.08.002

Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events

Melody El Chemaly, V. E. McGilligan, Mark Gibson, Matthias Clauss, Steven Watterson, H. Denis Alexander, AJ Bjourson, Aaron Peace

Research output: Contribution to journal › Article › peer-review

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Abstract

Summary Tumour necrosis factor alpha converting enzyme (TACE/ADAM17) is a member of the A disintegrin and metalloproteinase (ADAM) family of ectodomain shedding proteinases. It regulates many inflammatory processes by cleaving several transmembrane proteins, including tumour necrosis factor alpha (TNFalpha) and its receptors tumour necrosis factor alpha receptor 1 and tumour necrosis factor alpha receptor 2. There is evidence that TACE is involved in several TACE inflammatory diseases, such as ischaemia, heart failure, arthritis, atherosclerosis, diabetes and cancer as well as neurological and immune diseases. This review summarizes the latest discoveries regarding the mechanism of action and regulation of TACE. It also focuses on the role of TACE in atherosclerosis and coronary artery disease (CAD), highlighting clinical studies that have investigated its expression and protein activity. The multitude of substrates cleaved by TACE make this enzyme an attractive target for therapy and a candidate for biomarker research and development in CAD.

Original language	English
Article number	ACVD-1047
Pages (from-to)	700-711
Number of pages	12
Journal	Archives of Cardiovascular Diseases
Volume	110
Issue number	12
Early online date	31 Oct 2017
DOIs	https://doi.org/10.1016/j.acvd.2017.08.002
Publication status	E-pub ahead of print - 31 Oct 2017

Keywords

Atherosclerosis, Transmembrane proteins, TNFα, Biomarker, TACE

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El Chemaly, M., McGilligan, V. E., Gibson, M., Clauss, M., Watterson, S., Alexander, H. D., Bjourson, AJ., & Peace, A. (2017). Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events. Archives of Cardiovascular Diseases, 110(12), 700-711. [ACVD-1047]. https://doi.org/10.1016/j.acvd.2017.08.002

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abstract = "Summary Tumour necrosis factor alpha converting enzyme (TACE/ADAM17) is a member of the A disintegrin and metalloproteinase (ADAM) family of ectodomain shedding proteinases. It regulates many inflammatory processes by cleaving several transmembrane proteins, including tumour necrosis factor alpha (TNFalpha) and its receptors tumour necrosis factor alpha receptor 1 and tumour necrosis factor alpha receptor 2. There is evidence that TACE is involved in several TACE inflammatory diseases, such as ischaemia, heart failure, arthritis, atherosclerosis, diabetes and cancer as well as neurological and immune diseases. This review summarizes the latest discoveries regarding the mechanism of action and regulation of TACE. It also focuses on the role of TACE in atherosclerosis and coronary artery disease (CAD), highlighting clinical studies that have investigated its expression and protein activity. The multitude of substrates cleaved by TACE make this enzyme an attractive target for therapy and a candidate for biomarker research and development in CAD.",

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El Chemaly, M, McGilligan, VE, Gibson, M, Clauss, M, Watterson, S, Alexander, HD, Bjourson, AJ & Peace, A 2017, 'Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events', Archives of Cardiovascular Diseases, vol. 110, no. 12, ACVD-1047, pp. 700-711. https://doi.org/10.1016/j.acvd.2017.08.002

Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events. / El Chemaly, Melody; McGilligan, V. E.; Gibson, Mark; Clauss, Matthias ; Watterson, Steven; Alexander, H. Denis; Bjourson, AJ; Peace, Aaron.

In: Archives of Cardiovascular Diseases, Vol. 110, No. 12, ACVD-1047, 31.10.2017, p. 700-711.

Research output: Contribution to journal › Article › peer-review

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AU - El Chemaly, Melody

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AU - Gibson, Mark

AU - Clauss, Matthias

AU - Watterson, Steven

AU - Alexander, H. Denis

AU - Bjourson, AJ

AU - Peace, Aaron

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AB - Summary Tumour necrosis factor alpha converting enzyme (TACE/ADAM17) is a member of the A disintegrin and metalloproteinase (ADAM) family of ectodomain shedding proteinases. It regulates many inflammatory processes by cleaving several transmembrane proteins, including tumour necrosis factor alpha (TNFalpha) and its receptors tumour necrosis factor alpha receptor 1 and tumour necrosis factor alpha receptor 2. There is evidence that TACE is involved in several TACE inflammatory diseases, such as ischaemia, heart failure, arthritis, atherosclerosis, diabetes and cancer as well as neurological and immune diseases. This review summarizes the latest discoveries regarding the mechanism of action and regulation of TACE. It also focuses on the role of TACE in atherosclerosis and coronary artery disease (CAD), highlighting clinical studies that have investigated its expression and protein activity. The multitude of substrates cleaved by TACE make this enzyme an attractive target for therapy and a candidate for biomarker research and development in CAD.

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