TY - JOUR
T1 - Role of Serine/Threonine Kinase 11 (STK11) or liver kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome
AU - Altamish, Mohammad
AU - Dahiya, Rajiv
AU - Singh, Avinash Kumar
AU - Mishra, Anurag
AU - Aljabali, Alaa A. A.
AU - Satija, Saurabh
AU - Mehta, Meenu
AU - Dureja, Harish
AU - Prasher, Parteek
AU - Negi, Poonam
AU - Kapoor, Deepak N.
AU - Goyal, Rohit
AU - Tambuwala, Murtaza M
AU - Chellappan, Dinesh K.
AU - Dua, Kamal
AU - Gupta, Gaurav
PY - 2020/5/12
Y1 - 2020/5/12
N2 - Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 or STK11, which maps to chromosome subband 19p13.3. This gene has a putative coding region of 1302 bp, divided into nine exons, and acts as a tumor suppressor in the hamartomatous polyps of PJS patients and in the other neoplasms that develop in PJS patients. It is probable that these neoplasms develop from hamartomas, but it remains possible that the LKB1 or STK11 locus plays a role in a different genetic pathway of tumor growth in the cancers of PJS patients. This article focuses on the role of LKB1 or STK11 gene expression in PJS and related cancers.
AB - Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 or STK11, which maps to chromosome subband 19p13.3. This gene has a putative coding region of 1302 bp, divided into nine exons, and acts as a tumor suppressor in the hamartomatous polyps of PJS patients and in the other neoplasms that develop in PJS patients. It is probable that these neoplasms develop from hamartomas, but it remains possible that the LKB1 or STK11 locus plays a role in a different genetic pathway of tumor growth in the cancers of PJS patients. This article focuses on the role of LKB1 or STK11 gene expression in PJS and related cancers.
KW - Gastrointestinal polyps
KW - Gene expression
KW - LKB1
KW - Peutz-Jeghers syndrome
KW - STK11
UR - http://www.scopus.com/inward/record.url?scp=85088985724&partnerID=8YFLogxK
UR - http://dl.begellhouse.com/journals/6dbf508d3b17c437,forthcoming,33451.html
U2 - 10.1615/CritRevEukaryotGeneExpr.2020033451
DO - 10.1615/CritRevEukaryotGeneExpr.2020033451
M3 - Article
C2 - 32749111
SN - 1045-4403
VL - 30
SP - 245
EP - 252
JO - Critical Reviews in Eukaryotic Gene Expression
JF - Critical Reviews in Eukaryotic Gene Expression
IS - 3
ER -
