Role of Serine/Threonine Kinase 11 (STK11) or liver kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome

Mohammad Altamish, Rajiv Dahiya, Avinash Kumar Singh, Anurag Mishra, Alaa A. A. Aljabali, Saurabh Satija, Meenu Mehta, Harish Dureja, Parteek Prasher, Poonam Negi, Deepak N. Kapoor, Rohit Goyal, Murtaza M Tambuwala, Dinesh K. Chellappan, Kamal Dua, Gaurav Gupta

Research output: Contribution to journalArticle

Abstract

Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 or STK11, which maps to chromosome subband 19p13.3. This gene has a putative coding region of 1302 bp, divided into nine exons, and acts as a tumor suppressor in the hamartomatous polyps of PJS patients and in the other neoplasms that develop in PJS patients. It is probable that these neoplasms develop from hamartomas, but it remains possible that the LKB1 or STK11 locus plays a role in a different genetic pathway of tumor growth in the cancers of PJS patients. This article focuses on the role of LKB1 or STK11 gene expression in PJS and related cancers.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalCritical Reviews in Eukaryotic Gene Expression
Volume30
Issue number3
Early online date12 May 2020
DOIs
Publication statusE-pub ahead of print - 12 May 2020

Keywords

  • Gastrointestinal polyps
  • Gene expression
  • LKB1
  • Peutz-Jeghers syndrome
  • STK11

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    Altamish, M., Dahiya, R., Singh, A. K., Mishra, A., Aljabali, A. A. A., Satija, S., Mehta, M., Dureja, H., Prasher, P., Negi, P., Kapoor, D. N., Goyal, R., Tambuwala, M. M., Chellappan, D. K., Dua, K., & Gupta, G. (2020). Role of Serine/Threonine Kinase 11 (STK11) or liver kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome. Critical Reviews in Eukaryotic Gene Expression, 30(3), 245-252. https://doi.org/10.1615/CritRevEukaryotGeneExpr.2020033451