Role of radiation in DNA damage and radiation induced cancer

Vaishali Chandel; Gaurav Seth; Priyank Shukla; Dhruv Kumar

doi:10.1007/978-3-319-96511-6_1

Role of radiation in DNA damage and radiation induced cancer

Vaishali Chandel
, Gaurav Seth
, Priyank Shukla
, Dhruv Kumar

Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Sec-125, Noida, India

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Radiation has been reported to be a proven carcinogen which is responsible for more than half of all malignancies. The incident rates, morbidity and mortality of these cancers are increasing and thus reflects a serious health concern in public. Ionizing and Non-ionizing radiation exposure both lead to the development of cancer. Ultraviolet radiation (UVR) which is a non-ionizing radiation damages the DNA and causes genetic mutations. Exposure to Ionizing radiation results in the various oxidizing events altering the structure of atoms through direct interactions of the radiation with the target molecules or via the product of radiolysis of water. In this chapter we have discussed about the role of radiation in DNA damage and related mechanisms associated with cancer.

Original language	English
Title of host publication	Networking of Mutagens in Environmental Toxicology
Editors	Kavindra Kumar Kesari
Place of Publication	Cham, Switzerland
Pages	1-23
Number of pages	23
ISBN (Electronic)	978-3-319-96511-6
DOIs	https://doi.org/10.1007/978-3-319-96511-6_1
Publication status	Published (in print/issue) - 26 May 2019

Publication series

Name	Environmental Science and Engineering
ISSN (Print)	1863-5520
ISSN (Electronic)	1863-5539

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Radiation
DNA Damage
Mutation
Cancer

Access to Document

10.1007/978-3-319-96511-6_1

Cite this

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abstract = "Radiation has been reported to be a proven carcinogen which is responsible for more than half of all malignancies. The incident rates, morbidity and mortality of these cancers are increasing and thus reflects a serious health concern in public. Ionizing and Non-ionizing radiation exposure both lead to the development of cancer. Ultraviolet radiation (UVR) which is a non-ionizing radiation damages the DNA and causes genetic mutations. Exposure to Ionizing radiation results in the various oxidizing events altering the structure of atoms through direct interactions of the radiation with the target molecules or via the product of radiolysis of water. In this chapter we have discussed about the role of radiation in DNA damage and related mechanisms associated with cancer.",

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AU - Kumar, Dhruv

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AB - Radiation has been reported to be a proven carcinogen which is responsible for more than half of all malignancies. The incident rates, morbidity and mortality of these cancers are increasing and thus reflects a serious health concern in public. Ionizing and Non-ionizing radiation exposure both lead to the development of cancer. Ultraviolet radiation (UVR) which is a non-ionizing radiation damages the DNA and causes genetic mutations. Exposure to Ionizing radiation results in the various oxidizing events altering the structure of atoms through direct interactions of the radiation with the target molecules or via the product of radiolysis of water. In this chapter we have discussed about the role of radiation in DNA damage and related mechanisms associated with cancer.

KW - Radiation

KW - DNA Damage

KW - Mutation

KW - Cancer

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ER -

Role of radiation in DNA damage and radiation induced cancer

Abstract

Publication series

UN SDGs

Keywords

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