Role of Radiation in DNA Damage and Radiation Induced Cancer

Vaishali Chandel, Gaurav Seth, Priyank Shukla, Dhruv Kumar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Radiation has been reported to be a proven carcinogen which is responsible for more than half of all malignancies. The incident rates, morbidity and mortality of these cancers are increasing and thus reflects a serious health concern in public. Ionizing and Non-ionizing radiation exposure both lead to the development of cancer. Ultraviolet radiation (UVR) which is a non-ionizing radiation damages the DNA and causes genetic mutations. Exposure to Ionizing radiation results in the various oxidizing events altering the structure of atoms through direct interactions of the radiation with the target molecules or via the product of radiolysis of water. In this chapter we have discussed about the role of radiation in DNA damage and related mechanisms associated with cancer.
Original languageEnglish
Title of host publicationNetworking of Mutagens in Environmental Toxicology
EditorsKavindra Kumar Kesari
Place of PublicationCham, Switzerland
Pages1-23
Number of pages23
ISBN (Electronic)978-3-319-96511-6
DOIs
Publication statusPublished - 26 May 2019

Publication series

NameEnvironmental Science and Engineering
ISSN (Print)1863-5520
ISSN (Electronic)1863-5539

Keywords

  • Radiation
  • DNA Damage
  • Mutation
  • Cancer
  • DNA damage

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  • Cite this

    Chandel, V., Seth, G., Shukla, P., & Kumar, D. (2019). Role of Radiation in DNA Damage and Radiation Induced Cancer. In K. K. Kesari (Ed.), Networking of Mutagens in Environmental Toxicology (pp. 1-23). (Environmental Science and Engineering). Cham, Switzerland. https://doi.org/10.1007/978-3-319-96511-6_1