Role of mammalian Lignans in the prevention and treatment of prostate cancer

MJ McCann, Chris Gill, H McGlynn, IR Rowland

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Prostate cancer is poised to become the most prevalent male cancer in the Western world. In Japan and China, incidence rates are almost 10-fold less those reported in the United States and the European Union. Epidemiological data suggest that environmental factors. such as diet can. significantly influence the incidence and `Mortality of prostate cancer The differences in lifestyle between East and West are one of the major risk factors for developing prostate cancer Traditional Japanese and Chinese diets are rich in foods containing phytoestrogent. c compounds, whereas the Western diet is a poor source of these phytochemicals. The lignan phytoestrogens are the most widely occurring of these compounds. In vitro and in vivo reports in the literature indicate that lignans have the capacity to affect the pathogenesis of prostate cancer However their precise mechanism of action in prostate carcinogenesis remains unclear This article outlines the possible role of lignans in prostate cancer by reviewing the current in vitro and in `vivo evidence for their anticancer activities. The intriguing concept that lignans may play a role in the prevention and treatment of prostate cancer over the lifetime of an. individual is discussed.
LanguageEnglish
Pages1-14
JournalNUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Volume52
Issue number1
Publication statusPublished - 2005

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Lignans
Prostatic Neoplasms
Diet
Phytoestrogens
Western World
Incidence
Phytochemicals
European Union
Life Style
Prostate
China
Japan
Carcinogenesis
Food
Mortality
Neoplasms

Cite this

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Role of mammalian Lignans in the prevention and treatment of prostate cancer. / McCann, MJ; Gill, Chris; McGlynn, H; Rowland, IR.

In: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, Vol. 52, No. 1, 2005, p. 1-14.

Research output: Contribution to journalArticle

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AU - Gill, Chris

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AB - Prostate cancer is poised to become the most prevalent male cancer in the Western world. In Japan and China, incidence rates are almost 10-fold less those reported in the United States and the European Union. Epidemiological data suggest that environmental factors. such as diet can. significantly influence the incidence and `Mortality of prostate cancer The differences in lifestyle between East and West are one of the major risk factors for developing prostate cancer Traditional Japanese and Chinese diets are rich in foods containing phytoestrogent. c compounds, whereas the Western diet is a poor source of these phytochemicals. The lignan phytoestrogens are the most widely occurring of these compounds. In vitro and in vivo reports in the literature indicate that lignans have the capacity to affect the pathogenesis of prostate cancer However their precise mechanism of action in prostate carcinogenesis remains unclear This article outlines the possible role of lignans in prostate cancer by reviewing the current in vitro and in `vivo evidence for their anticancer activities. The intriguing concept that lignans may play a role in the prevention and treatment of prostate cancer over the lifetime of an. individual is discussed.

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