Role of branched-chain fatty acids in pH stress tolerance in Listeria monocytogenes

E S Giotis, DA McDowell, I S Blair, B J Wilkinson

    Research output: Contribution to journalArticle

    87 Citations (Scopus)
    70 Downloads (Pure)

    Abstract

    In alkaline conditions, Listeria monocytogenes cells develop higher proportions of branched-chain fatty acids (FAs), including more anteiso forms. In acid conditions, the opposite occurs. Reduced growth of pH-sensitive mutants at adverse pH (5.0/9.0) was alleviated by the addition of 2 -methylbutyrate (an anteiso-FA precursor), suggesting that anteiso-FAs are important in adaptation to adverse pH. The balance between anteiso- and iso-FAs may be more important than changes in the amounts and/or degrees of saturation of FAs in pH adaptation.
    Original languageEnglish
    Pages (from-to)997-1001
    JournalApplied and Environmental Microbiology
    Volume73
    Issue number3
    DOIs
    Publication statusPublished - 2007

    Keywords

    • membrane-lipid-composition
    • streptococcus-mutans
    • bacillus-subtilis
    • escherichia-coli
    • enhance survival
    • low-temperatures
    • growth
    • adaptation
    • resistance
    • biosynthesis

    Fingerprint Dive into the research topics of 'Role of branched-chain fatty acids in pH stress tolerance in Listeria monocytogenes'. Together they form a unique fingerprint.

    Cite this