Risk Factors, Clinical Consequences, Prevention, and Treatment of Childhood Obesity

Mossad Abdelhak Shaban Mohamed, Merna Mahmoud AbouKhatwa, Abdul Aziz Saifullah, Muhammad Hareez Syahmi, Mohamed Mosaad, Mahmoud E. Elrggal, Inderpal Singh Dehele, Mohamed Hassan Elnaem

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
32 Downloads (Pure)


Obesity might adversely affect the health and well-being of children and their families. Childhood obesity has crucial implications for health, both during childhood and as they age. It is highly associated with many acute problems and is commonly present during childhood, making visits and hospital admissions polarized in this group of children. The problems that may affect these children can be medical, such as asthma, chronic inflammation, orthopedic abnormalities, liver disease, diabetes mellitus or dyslipidemia. Long-term consequences of cardiovascular risk factors, the persistence of obesity and premature mortality are common among adults who had obesity during their early lives. Additionally, they could also suffer from psychological issues, such as low self-esteem, which puts them at risk of a much more serious psychosocial problem that may lead to depression, as well as a disruption in educational achievements and social relationships. A healthy diet, physical activity, adequate sleep, and limited screen time are all preventive measures that should be implemented at the family and community levels, preferably through well-structured programs. Furthermore, pharmacological management of childhood obesity is limited and only used after non-pharmacological interventions have failed or in the late stages of obesity. However, recent guidelines advocate the early use of medical interventions. Approved pharmacotherapeutic options include orlistat, phentermine/topiramate combination and liraglutide. There are several other options approved primarily for other specific forms of obesity or for other indications, including setmelanotide, metformin, lisdexamfetamine, zonisamide and fluoxetine. Bariatric surgery is a safe and effective option in cases with extreme obesity and comorbidities considering the need for long-term monitoring and support for cases and their families post-surgery. This review aims to discuss and highlight the recent evidence regarding risk factors, clinical consequences, prevention, and treatment of childhood obesity.
Original languageEnglish
Number of pages16
Issue number12
Early online date16 Dec 2022
Publication statusPublished online - 16 Dec 2022


  • risk factors
  • prevention
  • treatment
  • childhood
  • obesity


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