TY - JOUR
T1 - Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR.
AU - Horigan, G
AU - McNulty, H
AU - Ward, M
AU - STRAIN, JJ
AU - Purvis, J
AU - Scott, J.M.
PY - 2010/3
Y1 - 2010/3
N2 - Objective: The purpose was to examine the effect of intervention with riboflavin (a cofactor for MTHFR) on blood pressure in patients homozygous (TT genotype) for the common 677C->T polymorphism in MTHFR.Methods: We investigated 197 premature cardiovascular disease patients, prescreened for the MTHFR 677C->T polymorphism, from an original cohort of 404 to select those with the TT genotype (n = 60) and a similar number with heterozygous (CT; n = 85) or wild-type (CC; n = 75) genotypes. Of these, 181 completed an intervention in which participants were randomized within each genotype group to receive 1.6 mg per day riboflavin or placebo for 16 weeks.Results: Among patients taking one or more antihypertensive drugs at recruitment (82%), we observed that target blood pressure (
AB - Objective: The purpose was to examine the effect of intervention with riboflavin (a cofactor for MTHFR) on blood pressure in patients homozygous (TT genotype) for the common 677C->T polymorphism in MTHFR.Methods: We investigated 197 premature cardiovascular disease patients, prescreened for the MTHFR 677C->T polymorphism, from an original cohort of 404 to select those with the TT genotype (n = 60) and a similar number with heterozygous (CT; n = 85) or wild-type (CC; n = 75) genotypes. Of these, 181 completed an intervention in which participants were randomized within each genotype group to receive 1.6 mg per day riboflavin or placebo for 16 weeks.Results: Among patients taking one or more antihypertensive drugs at recruitment (82%), we observed that target blood pressure (
UR - https://www.scopus.com/pages/publications/77149145514
U2 - 10.1097/HJH.0b013e328334c126
DO - 10.1097/HJH.0b013e328334c126
M3 - Article
SN - 1473-5598
VL - 28
SP - 478
EP - 486
JO - Journal of Hypertension
JF - Journal of Hypertension
ER -
