Abstract
Objective: The purpose was to examine the effect of intervention with riboflavin (a cofactor for MTHFR) on blood pressure in patients homozygous (TT genotype) for the common 677C->T polymorphism in MTHFR.Methods: We investigated 197 premature cardiovascular disease patients, prescreened for the MTHFR 677C->T polymorphism, from an original cohort of 404 to select those with the TT genotype (n = 60) and a similar number with heterozygous (CT; n = 85) or wild-type (CC; n = 75) genotypes. Of these, 181 completed an intervention in which participants were randomized within each genotype group to receive 1.6 mg per day riboflavin or placebo for 16 weeks.Results: Among patients taking one or more antihypertensive drugs at recruitment (82%), we observed that target blood pressure (
Original language | English |
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Pages (from-to) | 478-486 |
Journal | Journal of Hypertension |
Volume | 28 |
DOIs | |
Publication status | Published (in print/issue) - Mar 2010 |