Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system

A. A. Zawislak, W. G. McCluggage, R. F. Donnelly, P. Maxwell, J. H. Price, S. P. Dobbs, H. R. McClelland, A. D. Woolfson, P. A. McCarron

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Abstract

This study evaluated the clinical and histopathological responses of vulval lichen sclerosus (LS) and squamous hyperplasia (SH) to photodynamic therapy (PDT). A novel bioadhesive patch containing aminolevulinic acid (ALA) at a dose of (38 mg/cm(2)) was used to treat 10 patients before irradiation with light of 630 nm. Clinical, histopathological and pathological responses to treatment were assessed at 6 weeks post-treatment. After 17 cycles of PDT, six patients reported significant symptomatic relief and no cutaneous photosensitivity. Histopathological differences were not demonstrated, but statistically significant induction of apoptosis was seen. It can be concluded that ALA-PDT patch-based formulation is pragmatic and primarily offers symptomatic management of vulval LS and SH.
LanguageEnglish
Pages111-113
JournalPhotodermatology, Photoimmunology & Photomedicine
Volume25
Issue number2
Publication statusPublished - 2009

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Lichen Sclerosus et Atrophicus
Aminolevulinic Acid
Photochemotherapy
Hyperplasia
Therapeutics
Apoptosis
Light
Skin

Cite this

Zawislak, A. A. ; McCluggage, W. G. ; Donnelly, R. F. ; Maxwell, P. ; Price, J. H. ; Dobbs, S. P. ; McClelland, H. R. ; Woolfson, A. D. ; McCarron, P. A. / Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system. In: Photodermatology, Photoimmunology & Photomedicine. 2009 ; Vol. 25, No. 2. pp. 111-113.
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abstract = "This study evaluated the clinical and histopathological responses of vulval lichen sclerosus (LS) and squamous hyperplasia (SH) to photodynamic therapy (PDT). A novel bioadhesive patch containing aminolevulinic acid (ALA) at a dose of (38 mg/cm(2)) was used to treat 10 patients before irradiation with light of 630 nm. Clinical, histopathological and pathological responses to treatment were assessed at 6 weeks post-treatment. After 17 cycles of PDT, six patients reported significant symptomatic relief and no cutaneous photosensitivity. Histopathological differences were not demonstrated, but statistically significant induction of apoptosis was seen. It can be concluded that ALA-PDT patch-based formulation is pragmatic and primarily offers symptomatic management of vulval LS and SH.",
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Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system. / Zawislak, A. A.; McCluggage, W. G.; Donnelly, R. F.; Maxwell, P.; Price, J. H.; Dobbs, S. P.; McClelland, H. R.; Woolfson, A. D.; McCarron, P. A.

In: Photodermatology, Photoimmunology & Photomedicine, Vol. 25, No. 2, 2009, p. 111-113.

Research output: Contribution to journalArticle

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AU - McCarron, P. A.

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