RELIABILITY OF REPORTED FAMILY HISTORY OF MYOCARDIAL-INFARCTION

F KEE, L TIRET, JY ROBO, V NICAUD, E MCCRUM, A EVANS, F CAMBIEN

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    Abstract

    Objective-To assess the reliability of reported family histories of myocardial infarction. Design-A case-control study in which reported histories of first degree relatives were validated from death certificates, general practitioners' records, and hospital notes. Setting-Participants enrolled in the Belfast centre of the World Health Organisation's study monitoring trends and determinants in cardiovascular disease (MONICA). Subjects-200 men who survived myocardial infarction and 200 age matched controls drawn randomly from the population. Main outcome measures-The sensitivity, specificity, positive predictive value, and proportion of overall agreement with validated records of reported family histories of myocardial infarction in first degree relatives; odds ratios for myocardial infarction, given at least one reported relative or at least one verified relative being affected. Results-349 of the 400 probands provided detailed family histories, reporting on 2812 first degree relatives. The overall sensitivity, specificity, and positive predictive value of reported histories were 67.3%, 96.5%, and 70.5% for cases and 68.5%, 97.7%, and 73.8% for controls. The K coefficients were modest: 0.65 for cases and 0.68 for controls. The odds ratios for myocardial infarction, given at least one affected relative, were not substantially inflated by recall bias. Some recall bias was evident for the probands' reports of their siblings' histories of myocardial infarction, the odds ratio for a reported history being 1.67 (95% confidence interval 1.09 to 2.57) and for the validated history 1.54 (1.01 to 2.37). Conclusions-Although the relative risk of disease is correctly estimated, the predictive accuracy of a casual family history of myocardial infarction may limit the effectiveness of targeted screening programmes. They may, however, complement other strategies based on genetic testing.
    LanguageEnglish
    Pages1528-1530
    JournalBRITISH MEDICAL JOURNAL
    Volume307
    Issue number6918
    Publication statusPublished - Dec 1993

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    Myocardial Infarction
    Odds Ratio
    History
    Sensitivity and Specificity
    Death Certificates
    Genetic Testing
    General Hospitals
    General Practitioners
    Case-Control Studies
    Siblings
    Cardiovascular Diseases
    Outcome Assessment (Health Care)
    Confidence Intervals
    Population

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    KEE, F., TIRET, L., ROBO, JY., NICAUD, V., MCCRUM, E., EVANS, A., & CAMBIEN, F. (1993). RELIABILITY OF REPORTED FAMILY HISTORY OF MYOCARDIAL-INFARCTION. BRITISH MEDICAL JOURNAL, 307(6918), 1528-1530.
    KEE, F ; TIRET, L ; ROBO, JY ; NICAUD, V ; MCCRUM, E ; EVANS, A ; CAMBIEN, F. / RELIABILITY OF REPORTED FAMILY HISTORY OF MYOCARDIAL-INFARCTION. In: BRITISH MEDICAL JOURNAL. 1993 ; Vol. 307, No. 6918. pp. 1528-1530.
    @article{fdf53176650d4627b203d76e783a7b53,
    title = "RELIABILITY OF REPORTED FAMILY HISTORY OF MYOCARDIAL-INFARCTION",
    abstract = "Objective-To assess the reliability of reported family histories of myocardial infarction. Design-A case-control study in which reported histories of first degree relatives were validated from death certificates, general practitioners' records, and hospital notes. Setting-Participants enrolled in the Belfast centre of the World Health Organisation's study monitoring trends and determinants in cardiovascular disease (MONICA). Subjects-200 men who survived myocardial infarction and 200 age matched controls drawn randomly from the population. Main outcome measures-The sensitivity, specificity, positive predictive value, and proportion of overall agreement with validated records of reported family histories of myocardial infarction in first degree relatives; odds ratios for myocardial infarction, given at least one reported relative or at least one verified relative being affected. Results-349 of the 400 probands provided detailed family histories, reporting on 2812 first degree relatives. The overall sensitivity, specificity, and positive predictive value of reported histories were 67.3{\%}, 96.5{\%}, and 70.5{\%} for cases and 68.5{\%}, 97.7{\%}, and 73.8{\%} for controls. The K coefficients were modest: 0.65 for cases and 0.68 for controls. The odds ratios for myocardial infarction, given at least one affected relative, were not substantially inflated by recall bias. Some recall bias was evident for the probands' reports of their siblings' histories of myocardial infarction, the odds ratio for a reported history being 1.67 (95{\%} confidence interval 1.09 to 2.57) and for the validated history 1.54 (1.01 to 2.37). Conclusions-Although the relative risk of disease is correctly estimated, the predictive accuracy of a casual family history of myocardial infarction may limit the effectiveness of targeted screening programmes. They may, however, complement other strategies based on genetic testing.",
    author = "F KEE and L TIRET and JY ROBO and V NICAUD and E MCCRUM and A EVANS and F CAMBIEN",
    year = "1993",
    month = "12",
    language = "English",
    volume = "307",
    pages = "1528--1530",
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    KEE, F, TIRET, L, ROBO, JY, NICAUD, V, MCCRUM, E, EVANS, A & CAMBIEN, F 1993, 'RELIABILITY OF REPORTED FAMILY HISTORY OF MYOCARDIAL-INFARCTION', BRITISH MEDICAL JOURNAL, vol. 307, no. 6918, pp. 1528-1530.

    RELIABILITY OF REPORTED FAMILY HISTORY OF MYOCARDIAL-INFARCTION. / KEE, F; TIRET, L; ROBO, JY; NICAUD, V; MCCRUM, E; EVANS, A; CAMBIEN, F.

    In: BRITISH MEDICAL JOURNAL, Vol. 307, No. 6918, 12.1993, p. 1528-1530.

    Research output: Contribution to journalArticle

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    T1 - RELIABILITY OF REPORTED FAMILY HISTORY OF MYOCARDIAL-INFARCTION

    AU - KEE, F

    AU - TIRET, L

    AU - ROBO, JY

    AU - NICAUD, V

    AU - MCCRUM, E

    AU - EVANS, A

    AU - CAMBIEN, F

    PY - 1993/12

    Y1 - 1993/12

    N2 - Objective-To assess the reliability of reported family histories of myocardial infarction. Design-A case-control study in which reported histories of first degree relatives were validated from death certificates, general practitioners' records, and hospital notes. Setting-Participants enrolled in the Belfast centre of the World Health Organisation's study monitoring trends and determinants in cardiovascular disease (MONICA). Subjects-200 men who survived myocardial infarction and 200 age matched controls drawn randomly from the population. Main outcome measures-The sensitivity, specificity, positive predictive value, and proportion of overall agreement with validated records of reported family histories of myocardial infarction in first degree relatives; odds ratios for myocardial infarction, given at least one reported relative or at least one verified relative being affected. Results-349 of the 400 probands provided detailed family histories, reporting on 2812 first degree relatives. The overall sensitivity, specificity, and positive predictive value of reported histories were 67.3%, 96.5%, and 70.5% for cases and 68.5%, 97.7%, and 73.8% for controls. The K coefficients were modest: 0.65 for cases and 0.68 for controls. The odds ratios for myocardial infarction, given at least one affected relative, were not substantially inflated by recall bias. Some recall bias was evident for the probands' reports of their siblings' histories of myocardial infarction, the odds ratio for a reported history being 1.67 (95% confidence interval 1.09 to 2.57) and for the validated history 1.54 (1.01 to 2.37). Conclusions-Although the relative risk of disease is correctly estimated, the predictive accuracy of a casual family history of myocardial infarction may limit the effectiveness of targeted screening programmes. They may, however, complement other strategies based on genetic testing.

    AB - Objective-To assess the reliability of reported family histories of myocardial infarction. Design-A case-control study in which reported histories of first degree relatives were validated from death certificates, general practitioners' records, and hospital notes. Setting-Participants enrolled in the Belfast centre of the World Health Organisation's study monitoring trends and determinants in cardiovascular disease (MONICA). Subjects-200 men who survived myocardial infarction and 200 age matched controls drawn randomly from the population. Main outcome measures-The sensitivity, specificity, positive predictive value, and proportion of overall agreement with validated records of reported family histories of myocardial infarction in first degree relatives; odds ratios for myocardial infarction, given at least one reported relative or at least one verified relative being affected. Results-349 of the 400 probands provided detailed family histories, reporting on 2812 first degree relatives. The overall sensitivity, specificity, and positive predictive value of reported histories were 67.3%, 96.5%, and 70.5% for cases and 68.5%, 97.7%, and 73.8% for controls. The K coefficients were modest: 0.65 for cases and 0.68 for controls. The odds ratios for myocardial infarction, given at least one affected relative, were not substantially inflated by recall bias. Some recall bias was evident for the probands' reports of their siblings' histories of myocardial infarction, the odds ratio for a reported history being 1.67 (95% confidence interval 1.09 to 2.57) and for the validated history 1.54 (1.01 to 2.37). Conclusions-Although the relative risk of disease is correctly estimated, the predictive accuracy of a casual family history of myocardial infarction may limit the effectiveness of targeted screening programmes. They may, however, complement other strategies based on genetic testing.

    M3 - Article

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    SP - 1528

    EP - 1530

    JO - BMJ

    T2 - BMJ

    JF - BMJ

    SN - 0959-8138

    IS - 6918

    ER -

    KEE F, TIRET L, ROBO JY, NICAUD V, MCCRUM E, EVANS A et al. RELIABILITY OF REPORTED FAMILY HISTORY OF MYOCARDIAL-INFARCTION. BRITISH MEDICAL JOURNAL. 1993 Dec;307(6918):1528-1530.