Regulation of ATP production by mitochondrial Ca2+

Andrei I. Tarasov, Elinor J. Griffiths, Guy A. Rutter

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Stimulation of mitochondrial oxidative metabolism by Ca2+ is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca2+ regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca2+-dependent regulation of ATP levels dynamically in single cells.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
JournalCell Calcium
Volume52
Issue number1
DOIs
Publication statusPublished - Jul 2012

Keywords

  • ATP
  • Beta cell
  • Calcium
  • Diabetes
  • Heart
  • Insulin
  • Islet
  • Mitochondria
  • Secretion

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