Regulation and feedback of cholesterol metabolism

Steven Watterson

doi:10.1038/npre.2011.6315.1

Regulation and feedback of cholesterol metabolism

Research output: Non-textual form › Web publication/site

Abstract

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. An integrative knowledge representation of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking. Here we provide using Systems Biology Graphical Notation the research synthesis of a process diagram integrating the regulatory and feedback systems for cholesterol synthesis.

Original language	English
DOIs	https://doi.org/10.1038/npre.2011.6315.1
Publication status	Published (in print/issue) - 31 Aug 2011

Keywords

SREBP-2
LXR
SBGN PD
cholesterol metabolism
25-hydroxycholesterol
network reconstruction
regulation
prenylation
dolichol synthesis
SBGN

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10.1038/npre.2011.6315.1

http://precedings.nature.com/documents/6315/version/1/files/npre20116315-1.pdf

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abstract = "Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. An integrative knowledge representation of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking. Here we provide using Systems Biology Graphical Notation the research synthesis of a process diagram integrating the regulatory and feedback systems for cholesterol synthesis.",

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AB - Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. An integrative knowledge representation of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking. Here we provide using Systems Biology Graphical Notation the research synthesis of a process diagram integrating the regulatory and feedback systems for cholesterol synthesis.

KW - SREBP-2

KW - LXR

KW - SBGN PD

KW - cholesterol metabolism

KW - 25-hydroxycholesterol

KW - network reconstruction

KW - regulation

KW - prenylation

KW - dolichol synthesis

KW - SBGN

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Regulation and feedback of cholesterol metabolism

Abstract

Keywords

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