Redox signaling and skeletal muscle adaptation during aerobic exercise

Yingsong Zhou, Xuan Zhang, Julien Baker, Gareth Davison, Xiaojun Yan

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Redox regulation is a fundamental physiological phenomenon related to oxygen-dependent metabolism, and skeletal muscle is mainly regarded as a primary site for oxidative phosphorylation. Several studies have revealed the importance of reactive oxygen and nitrogen species (RONS) in the signaling process relating to muscle adaptation during exercise. To date, improving knowledge of redox signaling in modulating exercise adaptation has been the subject of comprehensive work and scientific inquiry. The primary aim of this review is to elucidate the molecular and biochemical pathways aligned to RONS as activators of skeletal muscle adaptation and to further identify the interconnecting mechanisms controlling redox balance. We also discuss the RONS-mediated pathways during the muscle adaptive process, including mitochondrial biogenesis, muscle remodeling, vascular angiogenesis, neuron regeneration, and the role of exogenous antioxidants.
Original languageEnglish
Article number109643
Pages (from-to)1-20
Issue number5
Early online date29 Mar 2024
Publication statusPublished online - 29 Mar 2024

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© 2024 The Author(s)


  • Biological sciences
  • Cell biology
  • Cellular physiology
  • Molecular physiology


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