Redox signaling and skeletal muscle adaptation during aerobic exercise

Yingsong Zhou, Xuan Zhang, Julien Baker, Gareth Davison, Xiaojun Yan

Research output: Contribution to journalArticlepeer-review

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Abstract

Summary
Redox regulation is a fundamental physiological phenomenon related to oxygen-dependent metabolism, and skeletal muscle is mainly regarded as a primary site for oxidative phosphorylation. Several studies have revealed the importance of reactive oxygen and nitrogen species (RONS) in the signaling process relating to muscle adaptation during exercise. To date, improving knowledge of redox signaling in modulating exercise adaptation has been the subject of comprehensive work and scientific inquiry. The primary aim of this review is to elucidate the molecular and biochemical pathways aligned to RONS as activators of skeletal muscle adaptation and to further identify the interconnecting mechanisms controlling redox balance. We also discuss the RONS-mediated pathways during the muscle adaptive process, including mitochondrial biogenesis, muscle remodeling, vascular angiogenesis, neuron regeneration, and the role of exogenous antioxidants.
Original languageEnglish
Article number109643
Pages (from-to)1-20
JournaliScience
Volume27
Issue number5
Early online date29 Mar 2024
DOIs
Publication statusPublished online - 29 Mar 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s)

Keywords

  • Biological sciences
  • Cell biology
  • Cellular physiology
  • Molecular physiology

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