Reconstruction of the superior longitudinal fasciculus in a cohort of older healthy adults and those with mild cognitive impairment using CSD-based tractography

Elizabeth G. Kehoe, Xingfeng Li, Martin McGinnity, Brian Lawlor, Rose A Kenny, Damien Coyle, Arun L. W. Bokde

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The superior longitudinal fasciculus (SLF) is a large white matter tract connecting the parietal and frontal lobes, and is comprised of three branches. It is thought to play a crucial role in visuospatial attention and working memory. The recent development of spherical deconvolution-based tractography methods has enabled the complete reconstruction of the three branches of the SLF using diffusion imaging [1], however to date there have been no such studies in older adults or mild cognitive impairment (MCI). In the current study we sought to perform tractography of the SLF I, II and III in a cohort of older healthy adults and older adults with MCI using constrained spherical deconvolution (CSD)-based tractography, and to relate tract metrics to performance on neurocognitive tests.
LanguageEnglish
Title of host publicationUnknown Host Publication
Number of pages1
Publication statusPublished - 2013
EventISMRM Workshop on Diffusion as a Probe of Neural Tissue Microstructure - Croatia
Duration: 1 Jan 2013 → …

Workshop

WorkshopISMRM Workshop on Diffusion as a Probe of Neural Tissue Microstructure
Period1/01/13 → …

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Parietal Lobe
Frontal Lobe
Short-Term Memory
Cognitive Dysfunction
White Matter

Cite this

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title = "Reconstruction of the superior longitudinal fasciculus in a cohort of older healthy adults and those with mild cognitive impairment using CSD-based tractography",
abstract = "The superior longitudinal fasciculus (SLF) is a large white matter tract connecting the parietal and frontal lobes, and is comprised of three branches. It is thought to play a crucial role in visuospatial attention and working memory. The recent development of spherical deconvolution-based tractography methods has enabled the complete reconstruction of the three branches of the SLF using diffusion imaging [1], however to date there have been no such studies in older adults or mild cognitive impairment (MCI). In the current study we sought to perform tractography of the SLF I, II and III in a cohort of older healthy adults and older adults with MCI using constrained spherical deconvolution (CSD)-based tractography, and to relate tract metrics to performance on neurocognitive tests.",
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Kehoe, EG, Li, X, McGinnity, M, Lawlor, B, Kenny, RA, Coyle, D & Bokde, ALW 2013, Reconstruction of the superior longitudinal fasciculus in a cohort of older healthy adults and those with mild cognitive impairment using CSD-based tractography. in Unknown Host Publication. ISMRM Workshop on Diffusion as a Probe of Neural Tissue Microstructure, 1/01/13.

Reconstruction of the superior longitudinal fasciculus in a cohort of older healthy adults and those with mild cognitive impairment using CSD-based tractography. / Kehoe, Elizabeth G.; Li, Xingfeng; McGinnity, Martin; Lawlor, Brian; Kenny, Rose A; Coyle, Damien; Bokde, Arun L. W.

Unknown Host Publication. 2013.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - The superior longitudinal fasciculus (SLF) is a large white matter tract connecting the parietal and frontal lobes, and is comprised of three branches. It is thought to play a crucial role in visuospatial attention and working memory. The recent development of spherical deconvolution-based tractography methods has enabled the complete reconstruction of the three branches of the SLF using diffusion imaging [1], however to date there have been no such studies in older adults or mild cognitive impairment (MCI). In the current study we sought to perform tractography of the SLF I, II and III in a cohort of older healthy adults and older adults with MCI using constrained spherical deconvolution (CSD)-based tractography, and to relate tract metrics to performance on neurocognitive tests.

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