Recent developments in bioreactor scale production of bacterial polyhydroxyalkanoates

Zulfiqar Ali Raza, Muhammad Rizwan Tariq, Muhammad Irfan Majeed, Ibrahim Banat

Research output: Contribution to journalConference articlepeer-review

36 Citations (Scopus)
704 Downloads (Pure)


Polyhydroxyalkanoates (PHAs) are biological plastics that are sustainable alternative to synthetic ones. Numerous microorganisms have been identified as PHAs producers. They store PHAs as cellular inclusions to use as an energy source backup. They can be produced in shake flasks and in bioreactors under defined fermentation and physiological culture conditions using suitable nutrients. Their production at bioreactor scale depends on various factors such as carbon source, nutrients supply, temperature, dissolved oxygen level, pH, and production modes. Once produced, PHAs find diverse applications in multiple fields of science and technology particularly in the medical sector. The present review covers some recent developments in sustainable bioreactor scale production of PHAs and identifies some areas in which future research in this field might be focused.
Original languageEnglish
Pages (from-to)901-919
Number of pages19
JournalBioprocess and Biosystems Engineering
Issue number6
Early online date27 Feb 2019
Publication statusPublished (in print/issue) - 1 Jun 2019


  • Bioplastic · Biopolyester · Bioreactor · Fermentation · PHAs
  • Bioreactor
  • Biopolyester
  • Fermentation
  • Bioplastic
  • PHAs


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