Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis

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    Abstract

    A critical review of applications for the period 2000-2004, taken from the Web of Knowledge database, of the technique capillary electrophoresis-electrospray ionisation-mass spectrometry (CE-ESI-MS) in drug analysis is presented. The review is concerned with molecules of mass less than 500 Da, chosen according to selected structural classes in which they give ESI signals primarily as [M+H](+) ions although other ions, such as [M-H](-), [M+Na](+), and [M+NH4](+), are also reported. These structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, 1,4-benzodiazepines, other heterocyclic hypnotics, carbohydrates, sulphonylureas, anthracyclines, sulphonamides, penicillins, cephalosporins, tetracyclines, nitrocatechols, steroids, flavonoids/polyphenols, cannabinols, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole, and time of flight-mass spectrometers. The review gives a critical evaluation of these recent CE-ESI-MS analytical methods in drug analysis. Analytical information on, for example, sample concentration techniques, CE separation conditions, recoveries from biological media and limits of detection (LODs) are provided. Potential applications of CE-MS to particular drugs or drug classes are also briefly discussed in the text.
    LanguageEnglish
    Pages1334-1357
    JournalElectrophoresis
    Volume26
    Issue number7-8
    DOIs
    Publication statusPublished - Apr 2005

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    Capillary electrophoresis
    Electrospray ionization
    Mass spectrometry
    Pharmaceutical Preparations
    Ions
    Cannabinol
    Tetracyclines
    Molecules
    Anthracyclines
    Sulfonamides
    Polyphenols
    Mass spectrometers
    Cephalosporins
    Hypnotics and Sedatives
    Flavonoids
    Penicillins
    Amines
    Steroids
    Carbohydrates
    Recovery

    Cite this

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    title = "Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis",
    abstract = "A critical review of applications for the period 2000-2004, taken from the Web of Knowledge database, of the technique capillary electrophoresis-electrospray ionisation-mass spectrometry (CE-ESI-MS) in drug analysis is presented. The review is concerned with molecules of mass less than 500 Da, chosen according to selected structural classes in which they give ESI signals primarily as [M+H](+) ions although other ions, such as [M-H](-), [M+Na](+), and [M+NH4](+), are also reported. These structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, 1,4-benzodiazepines, other heterocyclic hypnotics, carbohydrates, sulphonylureas, anthracyclines, sulphonamides, penicillins, cephalosporins, tetracyclines, nitrocatechols, steroids, flavonoids/polyphenols, cannabinols, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole, and time of flight-mass spectrometers. The review gives a critical evaluation of these recent CE-ESI-MS analytical methods in drug analysis. Analytical information on, for example, sample concentration techniques, CE separation conditions, recoveries from biological media and limits of detection (LODs) are provided. Potential applications of CE-MS to particular drugs or drug classes are also briefly discussed in the text.",
    author = "Franklin Smyth",
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    Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis. / Smyth, Franklin.

    In: Electrophoresis, Vol. 26, No. 7-8, 04.2005, p. 1334-1357.

    Research output: Contribution to journalArticle

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