Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis

Franklin Smyth

    Research output: Contribution to journalArticle

    51 Citations (Scopus)

    Abstract

    This review considers applications in 2004-2005 of capillary electrophoresis-electrospray ionisation-mass spectrometry (CE-ESI-MS) to the detection and determination of small molecular mass drug molecules, taken from the Web of Knowledge database. The molecules of small molecular mass less than 1000 Da are chosen according to selected structural classes in which they give ESI signals primarily as [M+H](+) ions. These structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, 1,4-benzodiazepines, other heterocyclic hypnotics, steroids, bioactive compounds containing phenolic groups, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole and time-of flight mass spectrometers. The review then gives a critical evaluation of these recent CE-ESI-MS analytical methods for the detection and determination of these small molecular mass drug molecules. Analytical information on, for example, sample concentration techniques, CE separation conditions, recoveries from biological media and limits of detection are provided.
    LanguageEnglish
    Pages2051-2062
    JournalElectrophoresis
    Volume27
    Issue number11, Sp
    DOIs
    Publication statusPublished - Jun 2006

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    Capillary electrophoresis
    Electrospray ionization
    Mass spectrometry
    Molecular mass
    Molecules
    Pharmaceutical Preparations
    Ions
    Mass spectrometers
    Hypnotics and Sedatives
    Amines
    Steroids
    Recovery

    Cite this

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    abstract = "This review considers applications in 2004-2005 of capillary electrophoresis-electrospray ionisation-mass spectrometry (CE-ESI-MS) to the detection and determination of small molecular mass drug molecules, taken from the Web of Knowledge database. The molecules of small molecular mass less than 1000 Da are chosen according to selected structural classes in which they give ESI signals primarily as [M+H](+) ions. These structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, 1,4-benzodiazepines, other heterocyclic hypnotics, steroids, bioactive compounds containing phenolic groups, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole and time-of flight mass spectrometers. The review then gives a critical evaluation of these recent CE-ESI-MS analytical methods for the detection and determination of these small molecular mass drug molecules. Analytical information on, for example, sample concentration techniques, CE separation conditions, recoveries from biological media and limits of detection are provided.",
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    Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis. / Smyth, Franklin.

    In: Electrophoresis, Vol. 27, No. 11, Sp, 06.2006, p. 2051-2062.

    Research output: Contribution to journalArticle

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