Abstract
| Language | English |
|---|---|
| Pages | 2051-2062 |
| Journal | Electrophoresis |
| Volume | 27 |
| Issue number | 11, Sp |
| DOIs | |
| Publication status | Published - Jun 2006 |
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Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis. / Smyth, Franklin.
In: Electrophoresis, Vol. 27, No. 11, Sp, 06.2006, p. 2051-2062.Research output: Contribution to journal › Article
TY - JOUR
T1 - Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis
AU - Smyth, Franklin
PY - 2006/6
Y1 - 2006/6
N2 - This review considers applications in 2004-2005 of capillary electrophoresis-electrospray ionisation-mass spectrometry (CE-ESI-MS) to the detection and determination of small molecular mass drug molecules, taken from the Web of Knowledge database. The molecules of small molecular mass less than 1000 Da are chosen according to selected structural classes in which they give ESI signals primarily as [M+H](+) ions. These structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, 1,4-benzodiazepines, other heterocyclic hypnotics, steroids, bioactive compounds containing phenolic groups, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole and time-of flight mass spectrometers. The review then gives a critical evaluation of these recent CE-ESI-MS analytical methods for the detection and determination of these small molecular mass drug molecules. Analytical information on, for example, sample concentration techniques, CE separation conditions, recoveries from biological media and limits of detection are provided.
AB - This review considers applications in 2004-2005 of capillary electrophoresis-electrospray ionisation-mass spectrometry (CE-ESI-MS) to the detection and determination of small molecular mass drug molecules, taken from the Web of Knowledge database. The molecules of small molecular mass less than 1000 Da are chosen according to selected structural classes in which they give ESI signals primarily as [M+H](+) ions. These structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, 1,4-benzodiazepines, other heterocyclic hypnotics, steroids, bioactive compounds containing phenolic groups, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole and time-of flight mass spectrometers. The review then gives a critical evaluation of these recent CE-ESI-MS analytical methods for the detection and determination of these small molecular mass drug molecules. Analytical information on, for example, sample concentration techniques, CE separation conditions, recoveries from biological media and limits of detection are provided.
U2 - 10.1002/elps.200500524
DO - 10.1002/elps.200500524
M3 - Article
VL - 27
SP - 2051
EP - 2062
JO - Electrophoresis
T2 - Electrophoresis
JF - Electrophoresis
SN - 0173-0835
IS - 11, Sp
ER -