Recent advances in self-assembled nanoparticles for drug delivery

Lanke Tejesh Verma, Nidhi Singh, Bapi Gorain, Hira Choudhury, Murtaza M. Tambuwala, Prashant Kesharwani, Rahul Shukla

Research output: Contribution to journalArticle

Abstract

Collection of different bulk materials forms the nanoparticles, where the properties of the nanoparticle are solely differing from the individual components before ensemble. Self-assembled nanoparticles are basically a group of complex functional unit that are formed by assembly of the individual bulk components of the system. It includes micelles, polymeric nanoparticle, carbon nanotubes, liposomes and niosomes etc. This self-assembly has been progressively heightened interest to control the final complex structure of the nanoparticle and its associated properties. The main challenge of formulating self-assembled nanoparticle is to improve the delivery system, bioavailability, enhance circulation time, confer molecular targeting, controlled release, protection of the incorporated drug from external environment and also serves as nanocarriers for macromolecules. Ultimately, these self-assembled nanoparticles facilitate to overcome the physiological barriers in vivo. Self-assembly is equilibrium process where both individual and assembled components are subsisting in equilibrium. It is bottom up approach in which molecules are assembled spontaneously, non-covalently into stable and well-defined structure. There are different approaches has been adopted in fabrication of self-assembled nanoparticles by the researchers. The current review is enriched with strategies for nanoparticle self-assembly, associated properties, and its application in therapy.
Original languageEnglish
Number of pages13
JournalCurrent Drug Delivery
Volume17
DOIs
Publication statusPublished - 10 Feb 2020

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