Recent advances in self-assembled nanoparticles for drug delivery

Lanke Tejesh Verma, Nidhi Singh, Bapi Gorain, Hira Choudhury, Murtaza M. Tambuwala, Prashant Kesharwani, Rahul Shukla

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)
42 Downloads (Pure)

Abstract

The collection of different bulk materials forms the nanoparticles, where the properties of the nanoparticle are solely different from the individual components before being ensembled. Self-assembled nanoparticles are basically a group of complex functional units that are formed by gathering the individual bulk components of the system. It includes micelles, polymeric nanoparticle, carbon nano-tubes, liposomes and niosomes, etc. This self-assembly has progressively heightened interest to control the final complex structure of the nanoparticle and its associated properties. The main challenge of for-mulating self-assembled nanoparticle is to improve the delivery system, bioavailability, enhance circulation time, confer molecular targeting, controlled release, protection of the incorporated drug from exter-nal environment and also serve as nanocarriers for macromolecules. Ultimately, these self-assembled nanoparticles facilitate to overcome the physiological barriers in vivo. Self-assembly is an equilibrium process where both individual and assembled components are subsisting in equilibrium. It is a bottom up approach in which molecules are assembled spontaneously, non-covalently into a stable and well-defined structure. There are different approaches that have been adopted in fabrication of self-assembled nanoparticles by the researchers. The current review is enriched with strategies for nanoparticle self-assembly, associated properties, and its application in therapy.

Original languageEnglish
Pages (from-to)279-291
Number of pages13
JournalCurrent Drug Delivery
Volume17
Issue number4
DOIs
Publication statusPublished - 10 Feb 2020

Keywords

  • Driving forces
  • Gold nanoparticle
  • Liposome
  • Mesoporous silica nanoparticle
  • Nanoparticle
  • Self-assembly

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