Recent advances in self-assembled nanoparticles for drug delivery

Lanke Tejesh Verma, Nidhi Singh, Bapi Gorain, Hira Choudhury, Murtaza M. Tambuwala, Prashant Kesharwani, Rahul Shukla

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The collection of different bulk materials forms the nanoparticles, where the properties of the nanoparticle are solely different from the individual components before being ensembled. Self-assembled nanoparticles are basically a group of complex functional units that are formed by gathering the individual bulk components of the system. It includes micelles, polymeric nanoparticle, carbon nano-tubes, liposomes and niosomes, etc. This self-assembly has progressively heightened interest to control the final complex structure of the nanoparticle and its associated properties. The main challenge of for-mulating self-assembled nanoparticle is to improve the delivery system, bioavailability, enhance circulation time, confer molecular targeting, controlled release, protection of the incorporated drug from exter-nal environment and also serve as nanocarriers for macromolecules. Ultimately, these self-assembled nanoparticles facilitate to overcome the physiological barriers in vivo. Self-assembly is an equilibrium process where both individual and assembled components are subsisting in equilibrium. It is a bottom up approach in which molecules are assembled spontaneously, non-covalently into a stable and well-defined structure. There are different approaches that have been adopted in fabrication of self-assembled nanoparticles by the researchers. The current review is enriched with strategies for nanoparticle self-assembly, associated properties, and its application in therapy.

Original languageEnglish
Pages (from-to)279-291
Number of pages13
JournalCurrent Drug Delivery
Volume17
Issue number4
DOIs
Publication statusPublished - 10 Feb 2020

Keywords

  • Driving forces
  • Gold nanoparticle
  • Liposome
  • Mesoporous silica nanoparticle
  • Nanoparticle
  • Self-assembly

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    Verma, L. T., Singh, N., Gorain, B., Choudhury, H., Tambuwala, M. M., Kesharwani, P., & Shukla, R. (2020). Recent advances in self-assembled nanoparticles for drug delivery. Current Drug Delivery, 17(4), 279-291. https://doi.org/10.2174/1567201817666200210122340