TY - JOUR
T1 - Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma
AU - Gull, Nighat
AU - Arshad, Fareeha
AU - Naikoo, Gowhar A.
AU - Hassan, Israr Ul
AU - Pedram, Mona Zamani
AU - Ahmad, Arif
AU - Aljabali, Alaa A. A.
AU - Mishra, Vijay
AU - Satija, Saurabh
AU - Charbe, Nitin
AU - Negi, Poonam
AU - Goyal, Rohit
AU - Serrano-aroca, Ángel
AU - Al Zoubi, Mazhar S.
AU - El-tanani, Mohamed
AU - Tambuwala, Murtaza M.
N1 - Funding Information:
Nighat Gul and Arif Ahmed are grateful to University Grants Commission (UGC), New Delhi, India, for providing financial assistance to accomplish this work.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/3/14
Y1 - 2022/3/14
N2 - PurposeAmong all forms of cancers, hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. There are several treatment options for HCC ranging from loco-regional therapy to surgical treatment. Yet, there is high morbidity and mortality. Recent research focus has shifted towards more effective and less toxic cancer treatment options. Curcumin, the active ingredient in the Curcuma longa plant, has gained widespread attention in recent years because of its multifunctional properties as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent.MethodsA systematic search of PubMed, Embase and Google Scholar was performed for studies reporting incidence of HCC, risk factors associated with cirrhosis and experimental use of curcumin as an anti-cancer agent.ResultsThis review exclusively encompasses the anti-cancer properties of curcumin in HCC globally and it's postulated molecular targets of curcumin when used against liver cancers.ConclusionsThis review is concluded by presenting the current challenges and future perspectives of novel plant extracts derived from C. longa and the treatment options against cancers.
AB - PurposeAmong all forms of cancers, hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. There are several treatment options for HCC ranging from loco-regional therapy to surgical treatment. Yet, there is high morbidity and mortality. Recent research focus has shifted towards more effective and less toxic cancer treatment options. Curcumin, the active ingredient in the Curcuma longa plant, has gained widespread attention in recent years because of its multifunctional properties as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent.MethodsA systematic search of PubMed, Embase and Google Scholar was performed for studies reporting incidence of HCC, risk factors associated with cirrhosis and experimental use of curcumin as an anti-cancer agent.ResultsThis review exclusively encompasses the anti-cancer properties of curcumin in HCC globally and it's postulated molecular targets of curcumin when used against liver cancers.ConclusionsThis review is concluded by presenting the current challenges and future perspectives of novel plant extracts derived from C. longa and the treatment options against cancers.
KW - Cancer
KW - novel plant drugs
KW - Curcumin
KW - Anticancer
KW - Hepatocellular Carcinoma
UR - https://link.springer.com/10.1007/s12029-022-00809-z
UR - http://www.scopus.com/inward/record.url?scp=85126118544&partnerID=8YFLogxK
U2 - 10.1007/s12029-022-00809-z
DO - 10.1007/s12029-022-00809-z
M3 - Review article
C2 - 35285010
SN - 1941-6628
SP - 1
EP - 23
JO - Journal of Gastrointestinal Cancer
JF - Journal of Gastrointestinal Cancer
ER -
