Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma

Nighat Gull, Fareeha Arshad, Gowhar A. Naikoo, Israr Ul Hassan, Mona Zamani Pedram, Arif Ahmad, Alaa A. A. Aljabali, Vijay Mishra, Saurabh Satija, Nitin Charbe, Poonam Negi, Rohit Goyal, Ángel Serrano-aroca, Mazhar S. Al Zoubi, Mohamed El-tanani, Murtaza M. Tambuwala

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)
58 Downloads (Pure)


PurposeAmong all forms of cancers, hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. There are several treatment options for HCC ranging from loco-regional therapy to surgical treatment. Yet, there is high morbidity and mortality. Recent research focus has shifted towards more effective and less toxic cancer treatment options. Curcumin, the active ingredient in the Curcuma longa plant, has gained widespread attention in recent years because of its multifunctional properties as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent.MethodsA systematic search of PubMed, Embase and Google Scholar was performed for studies reporting incidence of HCC, risk factors associated with cirrhosis and experimental use of curcumin as an anti-cancer agent.ResultsThis review exclusively encompasses the anti-cancer properties of curcumin in HCC globally and it's postulated molecular targets of curcumin when used against liver cancers.ConclusionsThis review is concluded by presenting the current challenges and future perspectives of novel plant extracts derived from C. longa and the treatment options against cancers.
Original languageEnglish
Pages (from-to)1-23
Number of pages23
JournalJournal of Gastrointestinal Cancer
Early online date14 Mar 2022
Publication statusPublished online - 14 Mar 2022

Bibliographical note

Funding Information:
Nighat Gul and Arif Ahmed are grateful to University Grants Commission (UGC), New Delhi, India, for providing financial assistance to accomplish this work.

Publisher Copyright:
© 2022, The Author(s).


  • Cancer
  • novel plant drugs
  • Curcumin
  • Anticancer
  • Hepatocellular Carcinoma


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