Ratiometric fluorescent detection of Cu(II) in semi-aqueous solution using a two-fluorophore approach

Narinder Singh, Navneet Kaur, Bridgeen Callan, John Callan

Research output: Contribution to journalArticle

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Abstract

Schiff base sensor 1, containing naphthalene and naphthalimide fluorophores with separate and distinct emission wavelengths, showed good selectivity for Cu(II) over other tested physiological and environmentally important cations through changes in its fluorescence spectra in THF/H(2)O (9:1) HEPES buffered solution. By taking the ratiometric change of the emissions at 435 nm (naphthalene-Schiff base) and 510 nm (naphthalimide) good linearity was observed in the 0-10 mu M range. The enhancement of the 435 nm emission upon binding Cu(2+) was attributed to a prevention of the rapid C=N isomerisation that otherwise leads to non-radiative decay, while the quenching of the naphthalimide emission was attributed to electron transfer between the excited naphthalimide fluorophore and the redox active Cu(2+). (C) 2010 Elsevier Ltd. All rights reserved.
LanguageEnglish
Pages3385-3387
JournalTetrahedron Letters
Volume51
Issue number26
DOIs
Publication statusPublished - Jun 2010

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Naphthalimides
Fluorophores
Schiff Bases
HEPES
Isomerization
Cations
Quenching
Fluorescence
Wavelength
Electrons
Sensors

Cite this

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abstract = "Schiff base sensor 1, containing naphthalene and naphthalimide fluorophores with separate and distinct emission wavelengths, showed good selectivity for Cu(II) over other tested physiological and environmentally important cations through changes in its fluorescence spectra in THF/H(2)O (9:1) HEPES buffered solution. By taking the ratiometric change of the emissions at 435 nm (naphthalene-Schiff base) and 510 nm (naphthalimide) good linearity was observed in the 0-10 mu M range. The enhancement of the 435 nm emission upon binding Cu(2+) was attributed to a prevention of the rapid C=N isomerisation that otherwise leads to non-radiative decay, while the quenching of the naphthalimide emission was attributed to electron transfer between the excited naphthalimide fluorophore and the redox active Cu(2+). (C) 2010 Elsevier Ltd. All rights reserved.",
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Ratiometric fluorescent detection of Cu(II) in semi-aqueous solution using a two-fluorophore approach. / Singh, Narinder; Kaur, Navneet; Callan, Bridgeen; Callan, John.

Vol. 51, No. 26, 06.2010, p. 3385-3387.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Singh, Narinder

AU - Kaur, Navneet

AU - Callan, Bridgeen

AU - Callan, John

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AB - Schiff base sensor 1, containing naphthalene and naphthalimide fluorophores with separate and distinct emission wavelengths, showed good selectivity for Cu(II) over other tested physiological and environmentally important cations through changes in its fluorescence spectra in THF/H(2)O (9:1) HEPES buffered solution. By taking the ratiometric change of the emissions at 435 nm (naphthalene-Schiff base) and 510 nm (naphthalimide) good linearity was observed in the 0-10 mu M range. The enhancement of the 435 nm emission upon binding Cu(2+) was attributed to a prevention of the rapid C=N isomerisation that otherwise leads to non-radiative decay, while the quenching of the naphthalimide emission was attributed to electron transfer between the excited naphthalimide fluorophore and the redox active Cu(2+). (C) 2010 Elsevier Ltd. All rights reserved.

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