Rat and Mouse models of Salmonellosis

G Grant, M Duncan, Patrick Naughton

Research output: Contribution to conferenceAbstract

Abstract

S. typhimurium and S. enteritidis cause a lethal infection in susceptible (itys) mice, even at low infective doses. The disease partly resembles that elicited by S. typhi or S. paratyphi and is used as a model of typhoid-like illness. A major feature of the infection is uncontrolled proliferation of pathogen in systemic tissues and development of bacteraemia. This is atypical for S. typhimurium and S. enteritidis, which generally cause a self-limiting gastroenteritis in humans and domesticated animals. In contrast, the disease in the C3H/HeN mouse, whilst mainly gastrointestinal, had a significant systemic component and was not self-limiting. Nonetheless, both can be useful models for study of the effects of host, dietary and bacterial factors on pathogenicity.

Conference

ConferenceSociety of General Microbiology - 152nd ordinary meeting
CountryUnited Kingdom
CityEdinburgh
Period7/04/0311/04/03

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Salmonella Infections
Inbred C3H Mouse
Typhoid Fever
Domestic Animals
Gastroenteritis
Virulence Factors
Bacteremia
Infection

Cite this

Grant, G., Duncan, M., & Naughton, P. (2003). Rat and Mouse models of Salmonellosis. 76. Abstract from Society of General Microbiology - 152nd ordinary meeting, Edinburgh, United Kingdom.
Grant, G ; Duncan, M ; Naughton, Patrick. / Rat and Mouse models of Salmonellosis. Abstract from Society of General Microbiology - 152nd ordinary meeting, Edinburgh, United Kingdom.1 p.
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abstract = "S. typhimurium and S. enteritidis cause a lethal infection in susceptible (itys) mice, even at low infective doses. The disease partly resembles that elicited by S. typhi or S. paratyphi and is used as a model of typhoid-like illness. A major feature of the infection is uncontrolled proliferation of pathogen in systemic tissues and development of bacteraemia. This is atypical for S. typhimurium and S. enteritidis, which generally cause a self-limiting gastroenteritis in humans and domesticated animals. In contrast, the disease in the C3H/HeN mouse, whilst mainly gastrointestinal, had a significant systemic component and was not self-limiting. Nonetheless, both can be useful models for study of the effects of host, dietary and bacterial factors on pathogenicity.",
author = "G Grant and M Duncan and Patrick Naughton",
year = "2003",
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note = "Society of General Microbiology - 152nd ordinary meeting ; Conference date: 07-04-2003 Through 11-04-2003",

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Grant, G, Duncan, M & Naughton, P 2003, 'Rat and Mouse models of Salmonellosis' Society of General Microbiology - 152nd ordinary meeting, Edinburgh, United Kingdom, 7/04/03 - 11/04/03, pp. 76.

Rat and Mouse models of Salmonellosis. / Grant, G; Duncan, M; Naughton, Patrick.

2003. 76 Abstract from Society of General Microbiology - 152nd ordinary meeting, Edinburgh, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Rat and Mouse models of Salmonellosis

AU - Grant, G

AU - Duncan, M

AU - Naughton, Patrick

PY - 2003/4/7

Y1 - 2003/4/7

N2 - S. typhimurium and S. enteritidis cause a lethal infection in susceptible (itys) mice, even at low infective doses. The disease partly resembles that elicited by S. typhi or S. paratyphi and is used as a model of typhoid-like illness. A major feature of the infection is uncontrolled proliferation of pathogen in systemic tissues and development of bacteraemia. This is atypical for S. typhimurium and S. enteritidis, which generally cause a self-limiting gastroenteritis in humans and domesticated animals. In contrast, the disease in the C3H/HeN mouse, whilst mainly gastrointestinal, had a significant systemic component and was not self-limiting. Nonetheless, both can be useful models for study of the effects of host, dietary and bacterial factors on pathogenicity.

AB - S. typhimurium and S. enteritidis cause a lethal infection in susceptible (itys) mice, even at low infective doses. The disease partly resembles that elicited by S. typhi or S. paratyphi and is used as a model of typhoid-like illness. A major feature of the infection is uncontrolled proliferation of pathogen in systemic tissues and development of bacteraemia. This is atypical for S. typhimurium and S. enteritidis, which generally cause a self-limiting gastroenteritis in humans and domesticated animals. In contrast, the disease in the C3H/HeN mouse, whilst mainly gastrointestinal, had a significant systemic component and was not self-limiting. Nonetheless, both can be useful models for study of the effects of host, dietary and bacterial factors on pathogenicity.

M3 - Abstract

SP - 76

ER -

Grant G, Duncan M, Naughton P. Rat and Mouse models of Salmonellosis. 2003. Abstract from Society of General Microbiology - 152nd ordinary meeting, Edinburgh, United Kingdom.