S. typhimurium and S. enteritidis cause a lethal infection in susceptible (itys) mice, even at low infective doses. The disease partly resembles that elicited by S. typhi or S. paratyphi and is used as a model of typhoid-like illness. A major feature of the infection is uncontrolled proliferation of pathogen in systemic tissues and development of bacteraemia. This is atypical for S. typhimurium and S. enteritidis, which generally cause a self-limiting gastroenteritis in humans and domesticated animals. In contrast, the disease in the C3H/HeN mouse, whilst mainly gastrointestinal, had a significant systemic component and was not self-limiting. Nonetheless, both can be useful models for study of the effects of host, dietary and bacterial factors on pathogenicity.
|Number of pages||1|
|Publication status||Published - 7 Apr 2003|
|Event||Society of General Microbiology - 152nd ordinary meeting - University of Edinburgh, Edinburgh, United Kingdom|
Duration: 7 Apr 2003 → 11 Apr 2003
|Conference||Society of General Microbiology - 152nd ordinary meeting|
|Period||7/04/03 → 11/04/03|