Rapid Stoichiometric Analysis of G-Quadruplexes in Solution

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Guanine-rich sequences of nucleic acids may fold into secondarystructural folds called quadruplex architectures.These architectures are a rapidly growing theme of interestwith promising repercussions in our understanding of biologyand practical applications in medical fields, materialsscience, and biotechnology. Currently, there is thus interestin determining both topology and their atomic detail 3Dstructures. The establishment of solution conditions suitablefor structural studies of G-quadruplex architectures requiresthe determination of the level of oligomerization (stoichiometry)of DNA strands. Various analytical techniques arecurrently applied for the routine assessment of the stoichiometrythat generally include conditions not representativeof the environment in which the structural studies are performed.
LanguageEnglish
Pages6451-6453
JournalChem. Eur. J.
Volume16
DOIs
Publication statusPublished - 6 May 2010

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Oligomerization
Guanine
Biotechnology
Stoichiometry
Nucleic Acids
Topology
DNA

Cite this

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title = "Rapid Stoichiometric Analysis of G-Quadruplexes in Solution",
abstract = "Guanine-rich sequences of nucleic acids may fold into secondarystructural folds called quadruplex architectures.These architectures are a rapidly growing theme of interestwith promising repercussions in our understanding of biologyand practical applications in medical fields, materialsscience, and biotechnology. Currently, there is thus interestin determining both topology and their atomic detail 3Dstructures. The establishment of solution conditions suitablefor structural studies of G-quadruplex architectures requiresthe determination of the level of oligomerization (stoichiometry)of DNA strands. Various analytical techniques arecurrently applied for the routine assessment of the stoichiometrythat generally include conditions not representativeof the environment in which the structural studies are performed.",
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Rapid Stoichiometric Analysis of G-Quadruplexes in Solution. / Groves, P; Webba da Silva, Mateus.

In: Chem. Eur. J., Vol. 16, 06.05.2010, p. 6451-6453.

Research output: Contribution to journalArticle

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AU - Groves, P

AU - Webba da Silva, Mateus

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AB - Guanine-rich sequences of nucleic acids may fold into secondarystructural folds called quadruplex architectures.These architectures are a rapidly growing theme of interestwith promising repercussions in our understanding of biologyand practical applications in medical fields, materialsscience, and biotechnology. Currently, there is thus interestin determining both topology and their atomic detail 3Dstructures. The establishment of solution conditions suitablefor structural studies of G-quadruplex architectures requiresthe determination of the level of oligomerization (stoichiometry)of DNA strands. Various analytical techniques arecurrently applied for the routine assessment of the stoichiometrythat generally include conditions not representativeof the environment in which the structural studies are performed.

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T2 - Chemistry - A European Journal

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