RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population

Murtaza Tambuwala; Hamid Bakshi

doi:10.32471/exp-oncology.2312-8852.vol-43-no-2.16338

RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population

Murtaza Tambuwala
, Hamid Bakshi

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

135 Downloads (Pure)

Abstract

Background: Genetic predisposition to breast cancer (BC) has been extensively explored to achieve an enhanced understanding of the biology of BC. Targeting candidate genes to screen different genetic variants such as RAD51 gene that plays a critical role in DNA repair pathways including the double-strand break repair system is an important task.

Aim: To study several single nucleotide polymorphisms (SNPs) within RAD51-UTR gene and to find their relationship with BC risk and prognosis among Jordanian females.

Materials and methods: In this case-control study, DNA sequencing technique was used to screen SNPs within the untranslated region (UTR) of RAD51 in 206 cases and 185 controls and the resulting data were statistically analyzed using different types of genetic analyses. Patients' clinical and pathological features were obtained from their medical records to perform genotype-phenotype association analysis.

Results: Our findings show a significant association between both SNPs rs528590644, rs1801320 and BC risk (p = 0.016). We estimated the correlation between many of BC prognostic factors and BC risk, and we found an association between rs1801321 and age at first menstruation (p = 0.032) in addition to a strong correlation between age at BC diagnosis and rs1801320 (p = 0.008).

Conclusion: RAD51-UTR polymorphisms may be involved in BC development and progression.

Original language	English
Pages (from-to)	149-154
Number of pages	6
Journal	Experimental Oncology
Volume	43
Issue number	2
DOIs	https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-2.16338
Publication status	Published (in print/issue) - 30 Jun 2021

Bibliographical note

Funding Information:
This work was funded by the Deanship of Scientific Research and Graduate Studies at Yarmouk University (Grant ? 12/2015).

Publisher Copyright:
Copyright © Experimental Oncology, 2021

Funding

Funding Information: This work was funded by the Deanship of Scientific Research and Graduate Studies at Yarmouk University (Grant ? 12/2015). Publisher Copyright: Copyright © Experimental Oncology, 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Breast Cancer
genetic polymorphism

Access to Document

10.32471/exp-oncology.2312-8852.vol-43-no-2.16338

2738Final published version, 569 KB

Cite this

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title = "RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population",

abstract = "Background: Genetic predisposition to breast cancer (BC) has been extensively explored to achieve an enhanced understanding of the biology of BC. Targeting candidate genes to screen different genetic variants such as RAD51 gene that plays a critical role in DNA repair pathways including the double-strand break repair system is an important task. Aim: To study several single nucleotide polymorphisms (SNPs) within RAD51-UTR gene and to find their relationship with BC risk and prognosis among Jordanian females. Materials and methods: In this case-control study, DNA sequencing technique was used to screen SNPs within the untranslated region (UTR) of RAD51 in 206 cases and 185 controls and the resulting data were statistically analyzed using different types of genetic analyses. Patients' clinical and pathological features were obtained from their medical records to perform genotype-phenotype association analysis. Results: Our findings show a significant association between both SNPs rs528590644, rs1801320 and BC risk (p = 0.016). We estimated the correlation between many of BC prognostic factors and BC risk, and we found an association between rs1801321 and age at first menstruation (p = 0.032) in addition to a strong correlation between age at BC diagnosis and rs1801320 (p = 0.008). Conclusion: RAD51-UTR polymorphisms may be involved in BC development and progression.",

keywords = "Cancer, Breast Cancer, genetic polymorphism",

author = "Murtaza Tambuwala and Hamid Bakshi",

note = "Funding Information: This work was funded by the Deanship of Scientific Research and Graduate Studies at Yarmouk University (Grant ? 12/2015). Publisher Copyright: Copyright {\textcopyright} Experimental Oncology, 2021",

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doi = "10.32471/exp-oncology.2312-8852.vol-43-no-2.16338",

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AU - Tambuwala, Murtaza

AU - Bakshi, Hamid

N1 - Funding Information: This work was funded by the Deanship of Scientific Research and Graduate Studies at Yarmouk University (Grant ? 12/2015). Publisher Copyright: Copyright © Experimental Oncology, 2021

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N2 - Background: Genetic predisposition to breast cancer (BC) has been extensively explored to achieve an enhanced understanding of the biology of BC. Targeting candidate genes to screen different genetic variants such as RAD51 gene that plays a critical role in DNA repair pathways including the double-strand break repair system is an important task. Aim: To study several single nucleotide polymorphisms (SNPs) within RAD51-UTR gene and to find their relationship with BC risk and prognosis among Jordanian females. Materials and methods: In this case-control study, DNA sequencing technique was used to screen SNPs within the untranslated region (UTR) of RAD51 in 206 cases and 185 controls and the resulting data were statistically analyzed using different types of genetic analyses. Patients' clinical and pathological features were obtained from their medical records to perform genotype-phenotype association analysis. Results: Our findings show a significant association between both SNPs rs528590644, rs1801320 and BC risk (p = 0.016). We estimated the correlation between many of BC prognostic factors and BC risk, and we found an association between rs1801321 and age at first menstruation (p = 0.032) in addition to a strong correlation between age at BC diagnosis and rs1801320 (p = 0.008). Conclusion: RAD51-UTR polymorphisms may be involved in BC development and progression.

AB - Background: Genetic predisposition to breast cancer (BC) has been extensively explored to achieve an enhanced understanding of the biology of BC. Targeting candidate genes to screen different genetic variants such as RAD51 gene that plays a critical role in DNA repair pathways including the double-strand break repair system is an important task. Aim: To study several single nucleotide polymorphisms (SNPs) within RAD51-UTR gene and to find their relationship with BC risk and prognosis among Jordanian females. Materials and methods: In this case-control study, DNA sequencing technique was used to screen SNPs within the untranslated region (UTR) of RAD51 in 206 cases and 185 controls and the resulting data were statistically analyzed using different types of genetic analyses. Patients' clinical and pathological features were obtained from their medical records to perform genotype-phenotype association analysis. Results: Our findings show a significant association between both SNPs rs528590644, rs1801320 and BC risk (p = 0.016). We estimated the correlation between many of BC prognostic factors and BC risk, and we found an association between rs1801321 and age at first menstruation (p = 0.032) in addition to a strong correlation between age at BC diagnosis and rs1801320 (p = 0.008). Conclusion: RAD51-UTR polymorphisms may be involved in BC development and progression.

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RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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Molecular analysis of the effects of crocin on acute myeloid leukaemia, pancreatic and colon cancer

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RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Student theses

Molecular analysis of the effects of crocin on acute myeloid leukaemia, pancreatic and colon cancer

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