Questions concerning the proximal origin of SARS‐CoV‐2

Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El‐aziz; Sk. Sarif Hassan; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Murtaza Tambuwala; Alaa A. A. Aljabali; Amos Lal; Gajendra Kumar Azad; Pabitra Pal Choudhury; Vladimir N. Uversky; Samendra P. Sherchan; Bruce D. Uhal; Nima Rezaei; Adam M. Brufsky

doi:10.1002/jmv.26478

Questions concerning the proximal origin of SARS‐CoV‐2

Murat Seyran, Damiano Pizzol, Parise Adadi, Tarek Mohamed Abd El‐aziz, Sk. Sarif Hassan, Antonio Soares, Ramesh Kandimalla, Kenneth Lundstrom, Murtaza Tambuwala, Alaa A. A. Aljabali, Amos Lal, Gajendra Kumar Azad, Pabitra Pal Choudhury, Vladimir N. Uversky, Samendra P. Sherchan, Bruce D. Uhal, Nima Rezaei, Adam M. Brufsky

School of Pharm. & Pharmaceut. Sc.

Research output: Contribution to journal › Letter › peer-review

46 Citations (Scopus)

49 Downloads (Pure)

Abstract

There is a consensus that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) originated naturally from Bat coronaviruses (CoVs), in particular RaTG13. However, the SARS‐CoV‐2 host tropism/adaptation pattern has significant discrepancies compared to other CoVs, raising questions concerning the proximal origin of SARS‐CoV‐2.

Original language	English
Pages (from-to)	1204-1206
Number of pages	3
Journal	Journal of Medical Virology
Volume	93
Issue number	3
Early online date	3 Sept 2020
DOIs	https://doi.org/10.1002/jmv.26478
Publication status	Published (in print/issue) - 31 Mar 2021

Bibliographical note

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

coronavirus
fusion protein
genetic variability
mutation
Coronavirus/chemistry
Humans
RNA, Viral/genetics
Spike Glycoprotein, Coronavirus/chemistry
SARS-CoV-2/chemistry
Animals
COVID-19/epidemiology
Recombination, Genetic
Host Adaptation
Protein Binding
Protein Domains
Mutation
Viral Tropism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.26478

Journal of Medical Virology - 2020 - Seyran - Questions concerning the proximal origin of SARS‐CoV‐2Final published version, 499 KBLicence: CC BY

https://pubmed.ncbi.nlm.nih.gov/32880995/

Cite this

Seyran, M., Pizzol, D., Adadi, P., El‐aziz, T. M. A., Hassan, S. S., Soares, A., Kandimalla, R., Lundstrom, K., Tambuwala, M., Aljabali, A. A. A., Lal, A., Azad, G. K., Choudhury, P. P., Uversky, V. N., Sherchan, S. P., Uhal, B. D., Rezaei, N., & Brufsky, A. M. (2021). Questions concerning the proximal origin of SARS‐CoV‐2. Journal of Medical Virology, 93(3), 1204-1206. Advance online publication. https://doi.org/10.1002/jmv.26478

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author = "Murat Seyran and Damiano Pizzol and Parise Adadi and El‐aziz, {Tarek Mohamed Abd} and Hassan, {Sk. Sarif} and Antonio Soares and Ramesh Kandimalla and Kenneth Lundstrom and Murtaza Tambuwala and Aljabali, {Alaa A. A.} and Amos Lal and Azad, {Gajendra Kumar} and Choudhury, {Pabitra Pal} and Uversky, {Vladimir N.} and Sherchan, {Samendra P.} and Uhal, {Bruce D.} and Nima Rezaei and Brufsky, {Adam M.}",

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Seyran, M, Pizzol, D, Adadi, P, El‐aziz, TMA, Hassan, SS, Soares, A, Kandimalla, R, Lundstrom, K, Tambuwala, M, Aljabali, AAA, Lal, A, Azad, GK, Choudhury, PP, Uversky, VN, Sherchan, SP, Uhal, BD, Rezaei, N & Brufsky, AM 2021, 'Questions concerning the proximal origin of SARS‐CoV‐2', Journal of Medical Virology, vol. 93, no. 3, pp. 1204-1206. https://doi.org/10.1002/jmv.26478

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AU - Seyran, Murat

AU - Pizzol, Damiano

AU - Adadi, Parise

AU - El‐aziz, Tarek Mohamed Abd

AU - Hassan, Sk. Sarif

AU - Soares, Antonio

AU - Kandimalla, Ramesh

AU - Lundstrom, Kenneth

AU - Tambuwala, Murtaza

AU - Aljabali, Alaa A. A.

AU - Lal, Amos

AU - Azad, Gajendra Kumar

AU - Choudhury, Pabitra Pal

AU - Uversky, Vladimir N.

AU - Sherchan, Samendra P.

AU - Uhal, Bruce D.

AU - Rezaei, Nima

AU - Brufsky, Adam M.

PY - 2021/3/31

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N2 - There is a consensus that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) originated naturally from Bat coronaviruses (CoVs), in particular RaTG13. However, the SARS‐CoV‐2 host tropism/adaptation pattern has significant discrepancies compared to other CoVs, raising questions concerning the proximal origin of SARS‐CoV‐2.

AB - There is a consensus that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) originated naturally from Bat coronaviruses (CoVs), in particular RaTG13. However, the SARS‐CoV‐2 host tropism/adaptation pattern has significant discrepancies compared to other CoVs, raising questions concerning the proximal origin of SARS‐CoV‐2.

KW - coronavirus

KW - fusion protein

KW - genetic variability

KW - mutation

KW - Coronavirus/chemistry

KW - Humans

KW - RNA, Viral/genetics

KW - Spike Glycoprotein, Coronavirus/chemistry

KW - SARS-CoV-2/chemistry

KW - Animals

KW - COVID-19/epidemiology

KW - Recombination, Genetic

KW - Host Adaptation

KW - Protein Binding

KW - Protein Domains

KW - Mutation

KW - Viral Tropism

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U2 - 10.1002/jmv.26478

DO - 10.1002/jmv.26478

M3 - Letter

C2 - 32880995

SN - 0146-6615

VL - 93

SP - 1204

EP - 1206

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 3

ER -

Questions concerning the proximal origin of SARS‐CoV‐2

Abstract

Bibliographical note

Keywords

UN SDGs

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