Questions concerning the proximal origin of SARS‐CoV‐2

Murat Seyran, Damiano Pizzol, Parise Adadi, Tarek Mohamed Abd El‐aziz, Sk. Sarif Hassan, Antonio Soares, Ramesh Kandimalla, Kenneth Lundstrom, Murtaza Tambuwala, Alaa A. A. Aljabali, Amos Lal, Gajendra Kumar Azad, Pabitra Pal Choudhury, Vladimir N. Uversky, Samendra P. Sherchan, Bruce D. Uhal, Nima Rezaei, Adam M. Brufsky

Research output: Contribution to journalLetterpeer-review

47 Citations (Scopus)
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There is a consensus that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) originated naturally from Bat coronaviruses (CoVs), in particular RaTG13. However, the SARS‐CoV‐2 host tropism/adaptation pattern has significant discrepancies compared to other CoVs, raising questions concerning the proximal origin of SARS‐CoV‐2.
Original languageEnglish
Pages (from-to)1204-1206
Number of pages3
JournalJournal of Medical Virology
Issue number3
Early online date3 Sept 2020
Publication statusPublished (in print/issue) - 31 Mar 2021

Bibliographical note

Copyright 2021 Elsevier B.V., All rights reserved.


  • coronavirus
  • fusion protein
  • genetic variability
  • mutation
  • Coronavirus/chemistry
  • Humans
  • RNA, Viral/genetics
  • Spike Glycoprotein, Coronavirus/chemistry
  • SARS-CoV-2/chemistry
  • Animals
  • COVID-19/epidemiology
  • Recombination, Genetic
  • Host Adaptation
  • Protein Binding
  • Protein Domains
  • Mutation
  • Viral Tropism


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