Quantitative measurement of Upper limb motion pre- and post-treatment with Botulinum Toxin

Lu Bai; Matthew G. Pepper; Yong Yan; Malcolm Phillips; Mohamed Sakel

doi:10.1016/j.measurement.2020.108304

Quantitative measurement of Upper limb motion pre- and post-treatment with Botulinum Toxin

Lu Bai, Matthew G. Pepper, Yong Yan, Malcolm Phillips, Mohamed Sakel

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

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Abstract

Background: Muscle spasticity is a common motor complication after stroke and brain injury, and Botulinum Toxin is considered effective treatment for upper limb spasticity. However, clinical assessments are not possible to provide the quantitative measurement of changes happening on different upper limb segments. Methods: We aim to develop a multi-sensor system for quantitatively measurement of movement in all segments of upper limb. Five patients under neurorehabilitation were recruited to attend two-session rehabilitation assessment program to evaluate the changes before and one week after the Botulinum Toxin treatment. Results: Clinical assessments all improved in general (Disability Assessment Scale: p < 0.01). Analysis of Kinematic parameters and smoothness quantification parameters showed that number of movement units (p < 0.05 for elbow and wrist), normalised jerk scores improved for all upper limb segments. Conclusions: This study demonstrate that our multi-sensor inertial sensing system can provide additional insights for motion quantification pre and post the Botulinum Toxin treatment.

Original language	English
Article number	108304
Pages (from-to)	1-16
Number of pages	16
Journal	Measurement
Volume	168
Early online date	1 Aug 2020
DOIs	https://doi.org/10.1016/j.measurement.2020.108304
Publication status	Published (in print/issue) - 15 Jan 2021

Bibliographical note

Funding Information:
The authors are grateful to patients and staff of the East Kent NeuroRehabilitation Unit for supporting this University and Hospital’s jointly funded PhD project. We thank the University of Kent and East Kent Hospitals University NHS Foundation Trust (EKHUFT) for this PhD project funding.

Publisher Copyright:
© 2020 Elsevier Ltd

Keywords

Botulinum toxin
Kinematics
Quantitative measures
Upper limb function

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.measurement.2020.108304

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title = "Quantitative measurement of Upper limb motion pre- and post-treatment with Botulinum Toxin",

abstract = "Background: Muscle spasticity is a common motor complication after stroke and brain injury, and Botulinum Toxin is considered effective treatment for upper limb spasticity. However, clinical assessments are not possible to provide the quantitative measurement of changes happening on different upper limb segments. Methods: We aim to develop a multi-sensor system for quantitatively measurement of movement in all segments of upper limb. Five patients under neurorehabilitation were recruited to attend two-session rehabilitation assessment program to evaluate the changes before and one week after the Botulinum Toxin treatment. Results: Clinical assessments all improved in general (Disability Assessment Scale: p < 0.01). Analysis of Kinematic parameters and smoothness quantification parameters showed that number of movement units (p < 0.05 for elbow and wrist), normalised jerk scores improved for all upper limb segments. Conclusions: This study demonstrate that our multi-sensor inertial sensing system can provide additional insights for motion quantification pre and post the Botulinum Toxin treatment.",

keywords = "Botulinum toxin, Kinematics, Quantitative measures, Upper limb function",

author = "Lu Bai and Pepper, {Matthew G.} and Yong Yan and Malcolm Phillips and Mohamed Sakel",

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AU - Bai, Lu

AU - Pepper, Matthew G.

AU - Yan, Yong

AU - Phillips, Malcolm

AU - Sakel, Mohamed

N1 - Funding Information: The authors are grateful to patients and staff of the East Kent NeuroRehabilitation Unit for supporting this University and Hospital’s jointly funded PhD project. We thank the University of Kent and East Kent Hospitals University NHS Foundation Trust (EKHUFT) for this PhD project funding. Publisher Copyright: © 2020 Elsevier Ltd

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N2 - Background: Muscle spasticity is a common motor complication after stroke and brain injury, and Botulinum Toxin is considered effective treatment for upper limb spasticity. However, clinical assessments are not possible to provide the quantitative measurement of changes happening on different upper limb segments. Methods: We aim to develop a multi-sensor system for quantitatively measurement of movement in all segments of upper limb. Five patients under neurorehabilitation were recruited to attend two-session rehabilitation assessment program to evaluate the changes before and one week after the Botulinum Toxin treatment. Results: Clinical assessments all improved in general (Disability Assessment Scale: p < 0.01). Analysis of Kinematic parameters and smoothness quantification parameters showed that number of movement units (p < 0.05 for elbow and wrist), normalised jerk scores improved for all upper limb segments. Conclusions: This study demonstrate that our multi-sensor inertial sensing system can provide additional insights for motion quantification pre and post the Botulinum Toxin treatment.

AB - Background: Muscle spasticity is a common motor complication after stroke and brain injury, and Botulinum Toxin is considered effective treatment for upper limb spasticity. However, clinical assessments are not possible to provide the quantitative measurement of changes happening on different upper limb segments. Methods: We aim to develop a multi-sensor system for quantitatively measurement of movement in all segments of upper limb. Five patients under neurorehabilitation were recruited to attend two-session rehabilitation assessment program to evaluate the changes before and one week after the Botulinum Toxin treatment. Results: Clinical assessments all improved in general (Disability Assessment Scale: p < 0.01). Analysis of Kinematic parameters and smoothness quantification parameters showed that number of movement units (p < 0.05 for elbow and wrist), normalised jerk scores improved for all upper limb segments. Conclusions: This study demonstrate that our multi-sensor inertial sensing system can provide additional insights for motion quantification pre and post the Botulinum Toxin treatment.

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Quantitative measurement of Upper limb motion pre- and post-treatment with Botulinum Toxin

Abstract

Bibliographical note

Keywords

UN SDGs

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