QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

Paul G. O’Reilly; Qing Wen; Peter Bankhead; Philip D. Dunne; Darragh G. McArt; Suzanne McPherson; Peter W. Hamilton; Ken I. Mills; Shu-Dong Zhang

doi:10.1186/s12859-016-1062-1

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

Paul G. O’Reilly
, Qing Wen
, Peter Bankhead
, Philip D. Dunne
, Darragh G. McArt
, Suzanne McPherson
, Peter W. Hamilton
, Ken I. Mills
, Shu-Dong Zhang

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

85 Downloads (Pure)

Original language	English
Journal	BMC Bioinformatics
Volume	17
Issue number	198
DOIs	https://doi.org/10.1186/s12859-016-1062-1
Publication status	Published (in print/issue) - 4 May 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Connectivity mapping
Multicore programming
Big data
Repurposing
Drug discovery
Bioinformatics
Computational biology

Access to Document

10.1186/s12859-016-1062-1

2016-BMC-Bio-Qudratic-Fs12859-016-1062-1Final published version, 1.82 MB

Cite this

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title = "QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics",

keywords = "Connectivity mapping, Multicore programming, Big data, Repurposing, Drug discovery, Bioinformatics, Computational biology",

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AU - O’Reilly, Paul G.

AU - Wen, Qing

AU - Bankhead, Peter

AU - Dunne, Philip D.

AU - McArt, Darragh G.

AU - McPherson, Suzanne

AU - Hamilton, Peter W.

AU - Mills, Ken I.

AU - Zhang, Shu-Dong

PY - 2016/5/4

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KW - Connectivity mapping

KW - Multicore programming

KW - Big data

KW - Repurposing

KW - Drug discovery

KW - Bioinformatics

KW - Computational biology

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DO - 10.1186/s12859-016-1062-1

M3 - Article

SN - 1471-2105

VL - 17

JO - BMC Bioinformatics

JF - BMC Bioinformatics

IS - 198

ER -