QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

Paul G. O’Reilly; Qing Wen; Peter Bankhead; Philip D. Dunne; Darragh G. McArt; Suzanne McPherson; Peter W. Hamilton; Ken I. Mills; Shu-Dong Zhang

doi:10.1186/s12859-016-1062-1

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

Paul G. O’Reilly, Qing Wen, Peter Bankhead, Philip D. Dunne, Darragh G. McArt, Suzanne McPherson, Peter W. Hamilton, Ken I. Mills, Shu-Dong Zhang

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

60 Downloads (Pure)

Original language	English
Journal	BMC Bioinformatics
Volume	17
Issue number	198
DOIs	https://doi.org/10.1186/s12859-016-1062-1
Publication status	Published (in print/issue) - 4 May 2016

Keywords

Connectivity mapping
Multicore programming
Big data
Repurposing
Drug discovery
Bioinformatics
Computational biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12859-016-1062-1

2016-BMC-Bio-Qudratic-Fs12859-016-1062-1Final published version, 1.82 MB

Cite this

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title = "QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics",

keywords = "Connectivity mapping, Multicore programming, Big data, Repurposing, Drug discovery, Bioinformatics, Computational biology",

author = "O{\textquoteright}Reilly, {Paul G.} and Qing Wen and Peter Bankhead and Dunne, {Philip D.} and McArt, {Darragh G.} and Suzanne McPherson and Hamilton, {Peter W.} and Mills, {Ken I.} and Shu-Dong Zhang",

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AU - O’Reilly, Paul G.

AU - Wen, Qing

AU - Bankhead, Peter

AU - Dunne, Philip D.

AU - McArt, Darragh G.

AU - McPherson, Suzanne

AU - Hamilton, Peter W.

AU - Mills, Ken I.

AU - Zhang, Shu-Dong

PY - 2016/5/4

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KW - Connectivity mapping

KW - Multicore programming

KW - Big data

KW - Repurposing

KW - Drug discovery

KW - Bioinformatics

KW - Computational biology

U2 - 10.1186/s12859-016-1062-1

DO - 10.1186/s12859-016-1062-1

M3 - Article

SN - 1471-2105

VL - 17

JO - BMC Bioinformatics

JF - BMC Bioinformatics

IS - 198

ER -