PUFA Status and Methylmercury Exposure Are Not Associated with Leukocyte Telomere Length in Mothers or Their Children in the Seychelles Child Development Study

Alison J. Yeates, Sally, W, Thurston, Huiqi Li, Maria S Mulhern, Emeir M McSorley, Gene, E. Watson, Conrad, F. Shamlaye, JJ Strain, Gary, J. Myers, Philip, W. Davidson, Edwin Van Wijngaarden, Karin Broberg

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)
48 Downloads (Pure)

Abstract

Background Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on the determinants of TL in early life. Evidence suggests that dietary intake of marine n–3 (ω-3) polyunsaturated fatty acids (PUFAs) is protective of telomere attrition, yet the effect of methylmercury exposure, also found in fish, on TL is unknown. Objective The aim of this study was to investigate the associations between prenatal PUFA status, methylmercury exposure, and TL in mothers and children in the SCDS (Seychelles Child Development Study), for whom fish consumption is high. Methods Blood samples collected from 229 mothers (at 28 wk gestation and delivery) and children (at 5 y of age) in the SCDS first nutrition cohort were analyzed for PUFA concentrations. Prenatal mercury was measured in maternal hair collected at delivery. Postnatal mercury was also measured in children's hair samples with the use of a cumulative metric derived from values obtained at 3–5 y of age. Relative TL was measured in blood obtained from mothers at delivery, in cord blood, and in children at 5 y of age by quantitative polymerase chain reaction. Linear regression models were used to investigate the associations between PUFA status, methylmercury exposure, and TL. Results Neither prenatal PUFA status or methylmercury exposure was associated with TL of the mother or child or with TL attrition rate. However, a higher prenatal n–6:n–3 PUFA ratio was significantly associated with longer TLs in the mothers (β = 0.001, P = 0.048). Child PUFA status and methylmercury exposure were not associated with child TL. However, higher family Hollingshead socioeconomic status (SES) scores at 9 mo of age were significantly associated with longer TLs in cord blood (β = 0.005, P = 0.03). Conclusions We found no evidence that PUFA status or methylmercury exposure are determinants of TL in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL.
Original languageEnglish
Pages (from-to)2018-2024
JournalJournal of Nutrition
Volume147
Issue number11
Early online date4 Oct 2017
DOIs
Publication statusPublished (in print/issue) - 1 Nov 2017

Keywords

  • Polyunsaturated fatty acid status
  • methylmercury exposure
  • telomere length
  • pregnancy
  • maternal infant nutrition
  • fish consumption
  • Seychelles Child Development Study

Fingerprint

Dive into the research topics of 'PUFA Status and Methylmercury Exposure Are Not Associated with Leukocyte Telomere Length in Mothers or Their Children in the Seychelles Child Development Study'. Together they form a unique fingerprint.

Cite this