Psychosocial risk factors for heart disease in France and Northern Ireland: The prospective epidemiological study of myocardial infarction (PRIME)

DH Sykes, D Arveiler, CP Salters, J Ferrieres, E McCrum, P Amouyel, A Bingham, M Montaye, JB Ruidavets, B Haas, P Ducimetiere, AE Evans

    Research output: Contribution to journalArticle

    Abstract

    Background France has a substantially lower level of premature mortality from cardiovascular diseases (CVD) relative to its comparators. Compared with Northern Ireland, France has one-half the rate, despite having a similar cardiovascular risk profile to Northern Ireland. In this prospective longitudinal study the psychosocial risk hypothesis for CVD was tested. Method A cohort of 9758 men (7359 in France and 2399 in Northern Ireland) aged 50-59 years who were initially free of any CVD were recruited. At baseline the subjects completed a psychosocial questionnaire, measuring hostility, depression, social support, and the Type A behaviour pattern. At 5-years follow-up their clinical status was determined. Results Multivariate analysis indicated that, contrary to prediction, France had a substantially more negative psychosocial risk profile than Northern Ireland. The psychosocial risk factors were not successful at predicting at 5-years follow-up the hard clinical endpoint of definite fatal/non-fatal myocardial infarction. In the case of the softer clinical endpoint, angina pectoris/unstable angina, only depression predicted outcome with a small effect size. Conclusion The findings provide little support for the psychosocial risk hypothesis. The psychosocial risk profile was more negative in France, the opposite of that predicted. The finding of a relationship between depression and angina may reflect a tendency for individuals who respond negatively on mood state to report more cardiac symptoms irrespective of physical disease state.
    LanguageEnglish
    Pages1227-1234
    JournalInternational Journal of Epidemiology
    Volume31
    Issue number6
    Publication statusPublished - Dec 2002

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    Northern Ireland
    France
    Epidemiologic Studies
    Heart Diseases
    Myocardial Infarction
    Prospective Studies
    Psychology
    Cardiovascular Diseases
    Unstable Angina
    Depression
    Premature Mortality
    Hostility
    Social Support
    Longitudinal Studies
    Multivariate Analysis

    Cite this

    Sykes, DH., Arveiler, D., Salters, CP., Ferrieres, J., McCrum, E., Amouyel, P., ... Evans, AE. (2002). Psychosocial risk factors for heart disease in France and Northern Ireland: The prospective epidemiological study of myocardial infarction (PRIME). International Journal of Epidemiology, 31(6), 1227-1234.
    Sykes, DH ; Arveiler, D ; Salters, CP ; Ferrieres, J ; McCrum, E ; Amouyel, P ; Bingham, A ; Montaye, M ; Ruidavets, JB ; Haas, B ; Ducimetiere, P ; Evans, AE. / Psychosocial risk factors for heart disease in France and Northern Ireland: The prospective epidemiological study of myocardial infarction (PRIME). In: International Journal of Epidemiology. 2002 ; Vol. 31, No. 6. pp. 1227-1234.
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    abstract = "Background France has a substantially lower level of premature mortality from cardiovascular diseases (CVD) relative to its comparators. Compared with Northern Ireland, France has one-half the rate, despite having a similar cardiovascular risk profile to Northern Ireland. In this prospective longitudinal study the psychosocial risk hypothesis for CVD was tested. Method A cohort of 9758 men (7359 in France and 2399 in Northern Ireland) aged 50-59 years who were initially free of any CVD were recruited. At baseline the subjects completed a psychosocial questionnaire, measuring hostility, depression, social support, and the Type A behaviour pattern. At 5-years follow-up their clinical status was determined. Results Multivariate analysis indicated that, contrary to prediction, France had a substantially more negative psychosocial risk profile than Northern Ireland. The psychosocial risk factors were not successful at predicting at 5-years follow-up the hard clinical endpoint of definite fatal/non-fatal myocardial infarction. In the case of the softer clinical endpoint, angina pectoris/unstable angina, only depression predicted outcome with a small effect size. Conclusion The findings provide little support for the psychosocial risk hypothesis. The psychosocial risk profile was more negative in France, the opposite of that predicted. The finding of a relationship between depression and angina may reflect a tendency for individuals who respond negatively on mood state to report more cardiac symptoms irrespective of physical disease state.",
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    Sykes, DH, Arveiler, D, Salters, CP, Ferrieres, J, McCrum, E, Amouyel, P, Bingham, A, Montaye, M, Ruidavets, JB, Haas, B, Ducimetiere, P & Evans, AE 2002, 'Psychosocial risk factors for heart disease in France and Northern Ireland: The prospective epidemiological study of myocardial infarction (PRIME)', International Journal of Epidemiology, vol. 31, no. 6, pp. 1227-1234.

    Psychosocial risk factors for heart disease in France and Northern Ireland: The prospective epidemiological study of myocardial infarction (PRIME). / Sykes, DH; Arveiler, D; Salters, CP; Ferrieres, J; McCrum, E; Amouyel, P; Bingham, A; Montaye, M; Ruidavets, JB; Haas, B; Ducimetiere, P; Evans, AE.

    In: International Journal of Epidemiology, Vol. 31, No. 6, 12.2002, p. 1227-1234.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Psychosocial risk factors for heart disease in France and Northern Ireland: The prospective epidemiological study of myocardial infarction (PRIME)

    AU - Sykes, DH

    AU - Arveiler, D

    AU - Salters, CP

    AU - Ferrieres, J

    AU - McCrum, E

    AU - Amouyel, P

    AU - Bingham, A

    AU - Montaye, M

    AU - Ruidavets, JB

    AU - Haas, B

    AU - Ducimetiere, P

    AU - Evans, AE

    PY - 2002/12

    Y1 - 2002/12

    N2 - Background France has a substantially lower level of premature mortality from cardiovascular diseases (CVD) relative to its comparators. Compared with Northern Ireland, France has one-half the rate, despite having a similar cardiovascular risk profile to Northern Ireland. In this prospective longitudinal study the psychosocial risk hypothesis for CVD was tested. Method A cohort of 9758 men (7359 in France and 2399 in Northern Ireland) aged 50-59 years who were initially free of any CVD were recruited. At baseline the subjects completed a psychosocial questionnaire, measuring hostility, depression, social support, and the Type A behaviour pattern. At 5-years follow-up their clinical status was determined. Results Multivariate analysis indicated that, contrary to prediction, France had a substantially more negative psychosocial risk profile than Northern Ireland. The psychosocial risk factors were not successful at predicting at 5-years follow-up the hard clinical endpoint of definite fatal/non-fatal myocardial infarction. In the case of the softer clinical endpoint, angina pectoris/unstable angina, only depression predicted outcome with a small effect size. Conclusion The findings provide little support for the psychosocial risk hypothesis. The psychosocial risk profile was more negative in France, the opposite of that predicted. The finding of a relationship between depression and angina may reflect a tendency for individuals who respond negatively on mood state to report more cardiac symptoms irrespective of physical disease state.

    AB - Background France has a substantially lower level of premature mortality from cardiovascular diseases (CVD) relative to its comparators. Compared with Northern Ireland, France has one-half the rate, despite having a similar cardiovascular risk profile to Northern Ireland. In this prospective longitudinal study the psychosocial risk hypothesis for CVD was tested. Method A cohort of 9758 men (7359 in France and 2399 in Northern Ireland) aged 50-59 years who were initially free of any CVD were recruited. At baseline the subjects completed a psychosocial questionnaire, measuring hostility, depression, social support, and the Type A behaviour pattern. At 5-years follow-up their clinical status was determined. Results Multivariate analysis indicated that, contrary to prediction, France had a substantially more negative psychosocial risk profile than Northern Ireland. The psychosocial risk factors were not successful at predicting at 5-years follow-up the hard clinical endpoint of definite fatal/non-fatal myocardial infarction. In the case of the softer clinical endpoint, angina pectoris/unstable angina, only depression predicted outcome with a small effect size. Conclusion The findings provide little support for the psychosocial risk hypothesis. The psychosocial risk profile was more negative in France, the opposite of that predicted. The finding of a relationship between depression and angina may reflect a tendency for individuals who respond negatively on mood state to report more cardiac symptoms irrespective of physical disease state.

    M3 - Article

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    EP - 1234

    JO - International Journal of Epidemiology

    T2 - International Journal of Epidemiology

    JF - International Journal of Epidemiology

    SN - 0300-5771

    IS - 6

    ER -