Abstract
Objectives: Progressive lung disease, driven by inflammation secondary to chronicbacterial infection, constitutes the chief burden of CF.We describe a systems biologyinvestigation of the pathogenesis of Pseudomonas aeruginosa infected CF airwaysaiming to identify biomarkers/pathways as potential targets for improved therapyor for use as prognostic indicators.Methods: We employed multi-dimensional LC-MS/MS to semi-quantitatively contrastthe cellular protein profiles of sputum from CF and control cohorts. Importantly,our approach effectively assesses the activity of CF cells directly in theirin vivo environment, so taking into account the interactions between host and thehighly complex CF microbiome.Results: 119 of the 2309 human proteins detected were common to all samples(36 CF + 12 control). Of these, 49 were down-regulated and 29 up-regulatedin CF (p
Original language | English |
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Title of host publication | Journal of Cystic Fibrosis |
Publisher | Elsevier |
Pages | S26 |
Number of pages | 2 |
Volume | 11 |
Edition | 1 |
DOIs | |
Publication status | Published (in print/issue) - Jun 2012 |
Event | 35th European Cystic Fibrosis Conference - Dublin, Ireland Duration: 1 Jun 2012 → … |
Conference
Conference | 35th European Cystic Fibrosis Conference |
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Period | 1/06/12 → … |