Abstract
The study reveals previously unknown differences between the protein composition of GCD1 and LCD1 aggregates, and confirms the presence of the HtrA1 protease in LCD1-amyloid aggregates. In addition, we find mutation-specific differences in the processing of mutant TGFBIp species, which may contribute to the variable phenotypes noted in TGFBI-related dystrophies.
Original language | English |
---|---|
Pages (from-to) | 4653-4661 |
Number of pages | 8 |
Journal | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE |
Volume | 56 |
Issue number | 8 |
DOIs | |
Publication status | Published (in print/issue) - 2015 |
Keywords
- Transforming growth factor beta-induced
- Granular Corneal Dystrophy
- Lattice Corneal Dystrophy