Protein-based nanomaterials: a new tool for targeted drug delivery

Alaa AA Aljabali, Meriem Rezigue, Rawan H Alsharedeh, Mohammad A Obeid, Vijay Mishra, Ángel Serrano-Aroca, Mohamed El-Tanani, Murtaza M Tambuwala

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)
19 Downloads (Pure)


Protein nanomaterials are well-defined, hollow protein nanoparticles comprised of virus capsids, virus-like particles, ferritin, heat shock proteins, chaperonins and many more. Protein-based nanomaterials are formed by the self-assembly of protein subunits and have numerous desired properties as drug-delivery vehicles, including being optimally sized for endocytosis, nontoxic, biocompatible, biodegradable and functionalized at three separate interfaces (external, internal and intersubunit). As a result, protein nanomaterials have been intensively investigated as functional entities in bionanotechnology, including drug delivery, nanoreactors and templates for organic and inorganic nanomaterials. Several variables influence efficient administration, particularly active targeting, cellular uptake, the kinetics of the release and systemic elimination. This review examines the wide range of medicines, loading/release processes, targeted therapies and treatment effectiveness.
Original languageEnglish
Pages (from-to)321-338
Number of pages18
JournalTherapeutic Delivery
Issue number6
Publication statusPublished (in print/issue) - 4 Aug 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors.


  • Review
  • capsid proteins
  • nanotechnology
  • protein-based nanoparticles
  • targeted drug delivery
  • viruses
  • Nanoparticles
  • Proteins
  • Pharmaceutical Preparations
  • Nanostructures
  • Drug Delivery Systems


Dive into the research topics of 'Protein-based nanomaterials: a new tool for targeted drug delivery'. Together they form a unique fingerprint.

Cite this