Protein-based nanomaterials: a new tool for targeted drug delivery

Alaa AA Aljabali, Meriem Rezigue, Rawan H Alsharedeh, Mohammad A Obeid, Vijay Mishra, Ángel Serrano-Aroca, Mohamed El-Tanani, Murtaza M Tambuwala

Research output: Contribution to journalReview articlepeer-review

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Abstract

Protein nanomaterials are well-defined, hollow protein nanoparticles comprised of virus capsids, virus-like particles, ferritin, heat shock proteins, chaperonins and many more. Protein-based nanomaterials are formed by the self-assembly of protein subunits and have numerous desired properties as drug-delivery vehicles, including being optimally sized for endocytosis, nontoxic, biocompatible, biodegradable and functionalized at three separate interfaces (external, internal and intersubunit). As a result, protein nanomaterials have been intensively investigated as functional entities in bionanotechnology, including drug delivery, nanoreactors and templates for organic and inorganic nanomaterials. Several variables influence efficient administration, particularly active targeting, cellular uptake, the kinetics of the release and systemic elimination. This review examines the wide range of medicines, loading/release processes, targeted therapies and treatment effectiveness.
Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalTherapeutic Delivery
Early online date4 Aug 2022
DOIs
Publication statusE-pub ahead of print - 4 Aug 2022

Keywords

  • Review
  • capsid proteins
  • nanotechnology
  • protein-based nanoparticles
  • targeted drug delivery
  • viruses

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