Abstract
Protein nanomaterials are well-defined, hollow protein nanoparticles comprised of virus capsids, virus-like particles, ferritin, heat shock proteins, chaperonins and many more. Protein-based nanomaterials are formed by the self-assembly of protein subunits and have numerous desired properties as drug-delivery vehicles, including being optimally sized for endocytosis, nontoxic, biocompatible, biodegradable and functionalized at three separate interfaces (external, internal and intersubunit). As a result, protein nanomaterials have been intensively investigated as functional entities in bionanotechnology, including drug delivery, nanoreactors and templates for organic and inorganic nanomaterials. Several variables influence efficient administration, particularly active targeting, cellular uptake, the kinetics of the release and systemic elimination. This review examines the wide range of medicines, loading/release processes, targeted therapies and treatment effectiveness.
| Original language | English |
|---|---|
| Pages (from-to) | 321-338 |
| Number of pages | 18 |
| Journal | Therapeutic Delivery |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published (in print/issue) - 4 Aug 2022 |
Bibliographical note
Publisher Copyright:© 2022 The Authors.
Keywords
- Review
- capsid proteins
- nanotechnology
- protein-based nanoparticles
- targeted drug delivery
- viruses
- Nanoparticles
- Proteins
- Pharmaceutical Preparations
- Nanostructures
- Drug Delivery Systems
