Protein-Based Drug Delivery Nanomedicine Platforms: Recent Developments

Alaa A A Aljabali, Meriem Rezigue, Rawan H. Alsharedeh, Mohammad A. Obeid, Vijay Mishra, Ángel Serrano-Aroca, Murtaza M. Tambuwala

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Background: Naturally occurring protein cages, both viral and non-viral assemblies, have been developed for various pharmaceutical applications. Protein cages are ideal platforms as they are compatible, biodegradable, bioavailable, and amenable to chemical and genetic modification to impart new functionalities for selective targeting or tracking of proteins. The ferri-tin/apoferritin protein cage, plant-derived viral capsids, the small Heat shock protein, albumin, soy and whey protein, collagen, and gelatin have all been exploited and characterized as drug-delivery vehicles. Protein cages come in many shapes and types with unique features such as unmatched uniformity, size, and conjugations. Objectives: The recent strategic development of drug delivery will be covered in this review, emphasizing polymer-based, specifically protein-based, drug delivery nanomedicine platforms. The potential and drawbacks of each kind of protein-based drug-delivery system will also be highlighted. Methods: Research examining the usability of nanomaterials in the pharmaceutical and medical sectors were identified by employing bibliographic databases and web search engines. Results: Rings, tubes, and cages are unique protein structures that occur in the biological envi-ronment and might serve as building blocks for nanomachines. Furthermore, numerous virions can undergo reversible structural conformational changes that open or close gated pores, allowing customizable accessibility to their core and ideal delivery vehicles. Conclusion: Protein cages' biocompatibility and their ability to be precisely engineered indicate they have significant potential in drug delivery and intracellular administration.

Original languageEnglish
Pages (from-to)257-267
Number of pages11
JournalPharmaceutical Nanotechnology
Issue number4
Publication statusPublished (in print/issue) - 7 Oct 2022

Bibliographical note

Funding Information:
The study was supported by Deanship of scientific research at Yarmouk University, for funding the research project (grant number: 28/2021).

Publisher Copyright:
© 2022 Bentham Science Publishers.


  • Biomedical Engineering
  • Pharmaceutical Science
  • Protein nanoparticles
  • Pharmaceutical nanotechnology
  • viruses
  • Drug delivery
  • Nanomedicine
  • pharmaceutical nanotechnology
  • biocompatibility
  • nanomedicine
  • drug delivery


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