Prospected epigenetic moderators from natural sources and drug of class NSAIDS as effective treatment options to Prostate cancer

Vaibhav Dubey, Richard Owusu-apenten, Shipra Tripathi, Udaya Pratap Singh, Alok Semwal

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Abstract

Prostate cancer (PC) is one of the most common and leading cancer amongst the males all around the world. Depending upon it long latency and cost involved in its management and treatment, there is extensive need for more personalized and economical therapeutic approach for its effective therapy. The current review here discusses agents from natural dietary sources and drug class Non-Steroidal Antinflammatory (NSAIDS) that bears chemopreventive potential to regulate PC progression & tumour development and therefore could be devised into effective future treatment strategy against PC along with its metastatic castration-resistant form. Based on the literature search the therapeutic scope of selected agents are delineated, sighting their previous activity and prospects as epigenetic moderators in specific to particular PC causing biomarkers like over expression of AKR1C3, lost intracellular glutathione/glutathione-stranferases(GSH/GST) expression, DNA hypermethylation, aberrant cell proliferation and other related factors that are thought to potentiate and aggravate the onset of PC like smoking and use of other narcotics products.
Original languageEnglish
Pages (from-to)145-153
JournalJournal of Acute Disease
Volume6
Issue number4
Early online date1 Jul 2017
DOIs
Publication statusPublished online - 1 Jul 2017

Keywords

  • Prostate cancer
  • NSAIDS
  • AKRIC
  • GSH/GST
  • DNA hypermethylation

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