Propionibacterium acnes and acne vulgaris: new insights from the integration of population genetic, multi-omic, biochemical and host-microbe studies.

Joseph McLaughlin, Steven Watterson, Alison M Layton, AJ Bjourson, Emma Barnard, Andrew Mc Dowell

Research output: Contribution to journalArticle

Abstract

The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the common skin disease acne vulgaris. Over the last 10 years our understanding of the taxonomic and intraspecies diversity of this bacterium has increased tremendously, and with it the realisation that particular strains are associated with skin health while others appear related to disease. This extensive review will cover our current knowledge regarding the association of P. acnes phylogroups, clonal complexes and sequence types with acne vulgaris based on multilocus sequence typing of isolates, and direct ribotyping of the P. acnes strain population in skin microbiome samples based on 16S rDNA metagenomic data. We will also consider how multi-omic and biochemical studies have facilitated our understanding of P. acnes pathogenicity and interactions with the host, thus providing insights into why certain lineages appear to have a heightened capacity to contribute to acne vulgaris development, while others are positively associated with skin health. We conclude with a discussion of new therapeutic strategies that are currently under investigation for acne vulgaris, including vaccination, and consider the potential of these treatments to also perturb beneficial lineages of P. acnes on the skin.
LanguageEnglish
Pages1-29
Number of pages29
JournalMicroorganisms
Volume7
Issue number128
Publication statusPublished - 13 May 2019

Fingerprint

Propionibacterium acnes
Acne Vulgaris
Population Genetics
Skin
Ribotyping
Multilocus Sequence Typing
Metagenomics
Anaerobic Bacteria
Microbiota
Health
Ribosomal DNA
Skin Diseases
Virulence
Vaccination
Bacteria
Therapeutics
Population

Keywords

  • Propionibacterium acnes; Cutibacterium; phylogroups; MLST; clonal complex; sequence types; multi-omic analyses; virulence factors; host-microbe interactions; novel therapeutics; vaccination

Cite this

@article{37cf1fb5b7f34e01b24e4b930930e83f,
title = "Propionibacterium acnes and acne vulgaris: new insights from the integration of population genetic, multi-omic, biochemical and host-microbe studies.",
abstract = "The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the common skin disease acne vulgaris. Over the last 10 years our understanding of the taxonomic and intraspecies diversity of this bacterium has increased tremendously, and with it the realisation that particular strains are associated with skin health while others appear related to disease. This extensive review will cover our current knowledge regarding the association of P. acnes phylogroups, clonal complexes and sequence types with acne vulgaris based on multilocus sequence typing of isolates, and direct ribotyping of the P. acnes strain population in skin microbiome samples based on 16S rDNA metagenomic data. We will also consider how multi-omic and biochemical studies have facilitated our understanding of P. acnes pathogenicity and interactions with the host, thus providing insights into why certain lineages appear to have a heightened capacity to contribute to acne vulgaris development, while others are positively associated with skin health. We conclude with a discussion of new therapeutic strategies that are currently under investigation for acne vulgaris, including vaccination, and consider the potential of these treatments to also perturb beneficial lineages of P. acnes on the skin.",
keywords = "Propionibacterium acnes; Cutibacterium; phylogroups; MLST; clonal complex; sequence types; multi-omic analyses; virulence factors; host-microbe interactions; novel therapeutics; vaccination",
author = "Joseph McLaughlin and Steven Watterson and Layton, {Alison M} and AJ Bjourson and Emma Barnard and {Mc Dowell}, Andrew",
year = "2019",
month = "5",
day = "13",
language = "English",
volume = "7",
pages = "1--29",
journal = "Microorganisms",
issn = "2076-2607",
publisher = "MDPI",
number = "128",

}

Propionibacterium acnes and acne vulgaris: new insights from the integration of population genetic, multi-omic, biochemical and host-microbe studies. / McLaughlin, Joseph; Watterson, Steven; Layton, Alison M; Bjourson, AJ; Barnard, Emma; Mc Dowell, Andrew.

In: Microorganisms, Vol. 7, No. 128, 13.05.2019, p. 1-29.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Propionibacterium acnes and acne vulgaris: new insights from the integration of population genetic, multi-omic, biochemical and host-microbe studies.

AU - McLaughlin, Joseph

AU - Watterson, Steven

AU - Layton, Alison M

AU - Bjourson, AJ

AU - Barnard, Emma

AU - Mc Dowell, Andrew

PY - 2019/5/13

Y1 - 2019/5/13

N2 - The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the common skin disease acne vulgaris. Over the last 10 years our understanding of the taxonomic and intraspecies diversity of this bacterium has increased tremendously, and with it the realisation that particular strains are associated with skin health while others appear related to disease. This extensive review will cover our current knowledge regarding the association of P. acnes phylogroups, clonal complexes and sequence types with acne vulgaris based on multilocus sequence typing of isolates, and direct ribotyping of the P. acnes strain population in skin microbiome samples based on 16S rDNA metagenomic data. We will also consider how multi-omic and biochemical studies have facilitated our understanding of P. acnes pathogenicity and interactions with the host, thus providing insights into why certain lineages appear to have a heightened capacity to contribute to acne vulgaris development, while others are positively associated with skin health. We conclude with a discussion of new therapeutic strategies that are currently under investigation for acne vulgaris, including vaccination, and consider the potential of these treatments to also perturb beneficial lineages of P. acnes on the skin.

AB - The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the common skin disease acne vulgaris. Over the last 10 years our understanding of the taxonomic and intraspecies diversity of this bacterium has increased tremendously, and with it the realisation that particular strains are associated with skin health while others appear related to disease. This extensive review will cover our current knowledge regarding the association of P. acnes phylogroups, clonal complexes and sequence types with acne vulgaris based on multilocus sequence typing of isolates, and direct ribotyping of the P. acnes strain population in skin microbiome samples based on 16S rDNA metagenomic data. We will also consider how multi-omic and biochemical studies have facilitated our understanding of P. acnes pathogenicity and interactions with the host, thus providing insights into why certain lineages appear to have a heightened capacity to contribute to acne vulgaris development, while others are positively associated with skin health. We conclude with a discussion of new therapeutic strategies that are currently under investigation for acne vulgaris, including vaccination, and consider the potential of these treatments to also perturb beneficial lineages of P. acnes on the skin.

KW - Propionibacterium acnes; Cutibacterium; phylogroups; MLST; clonal complex; sequence types; multi-omic analyses; virulence factors; host-microbe interactions; novel therapeutics; vaccination

M3 - Article

VL - 7

SP - 1

EP - 29

JO - Microorganisms

T2 - Microorganisms

JF - Microorganisms

SN - 2076-2607

IS - 128

ER -