Programmed Self-Assembly of a Quadruplex DNA Nanowire

Nason Ma’ani Hessari, L Spindler, T Troha, W.C Lam, I Drevenšek-Olenik, Mateus Webba da Silva

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


The ability to produce, reproducibly and systematically, well-defined quadruplex DNA nanowires through controlled rational design is poorly understood despite potential utility in structural nanotechnology. The programmed hierarchical self-assembly of a long four-stranded DNA nanowire through cohesive self-assembly of GpC and CpG “sticky” ends is reported. The encoding of bases within the quadruplex stem allows for an uninterrupted pi-stacking system with rectilinear propagation for hundreds of nanometers in length. The wire is mechanically stable and features superior nuclease resistance to double-stranded DNA. The study indicates the feasibility for programmed assembly of uninterrupted quadruplex DNA nanowires. This is fundamental to the systematic investigation of well-defined DNA nanostructures for uses in optoelectronic and electronic devices as well as other structural nanotechnology applications.
Original languageEnglish
Pages (from-to)3626-3630
Number of pages5
JournalChemistry - A European Journal
Issue number13
Early online date25 Feb 2014
Publication statusPublished (in print/issue) - 24 Mar 2014


  • DNA
  • G-quadruplexes
  • G-wire
  • nanowires
  • self-assembly


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