Abstract
The ability to produce, reproducibly and systematically, well-defined quadruplex DNA nanowires through controlled rational design is poorly understood despite potential utility in structural nanotechnology. The programmed hierarchical self-assembly of a long four-stranded DNA nanowire through cohesive self-assembly of GpC and CpG “sticky” ends is reported. The encoding of bases within the quadruplex stem allows for an uninterrupted pi-stacking system with rectilinear propagation for hundreds of nanometers in length. The wire is mechanically stable and features superior nuclease resistance to double-stranded DNA. The study indicates the feasibility for programmed assembly of uninterrupted quadruplex DNA nanowires. This is fundamental to the systematic investigation of well-defined DNA nanostructures for uses in optoelectronic and electronic devices as well as other structural nanotechnology applications.
Original language | English |
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Pages (from-to) | 3626-3630 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 20 |
Issue number | 13 |
Early online date | 25 Feb 2014 |
DOIs | |
Publication status | Published (in print/issue) - 24 Mar 2014 |
Keywords
- DNA
- G-quadruplexes
- G-wire
- nanowires
- self-assembly
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Mateus Webba Da Silva
- School of Pharm. & Pharmaceut. Sc. - Reader of Pharmaceutical Chemistry
- Faculty Of Life & Health Sciences - Reader
Person: Academic