The ability to produce, reproducibly and systematically, well-defined quadruplex DNA nanowires through controlled rational design is poorly understood despite potential utility in structural nanotechnology. The programmed hierarchical self-assembly of a long four-stranded DNA nanowire through cohesive self-assembly of GpC and CpG “sticky” ends is reported. The encoding of bases within the quadruplex stem allows for an uninterrupted pi-stacking system with rectilinear propagation for hundreds of nanometers in length. The wire is mechanically stable and features superior nuclease resistance to double-stranded DNA. The study indicates the feasibility for programmed assembly of uninterrupted quadruplex DNA nanowires. This is fundamental to the systematic investigation of well-defined DNA nanostructures for uses in optoelectronic and electronic devices as well as other structural nanotechnology applications.
Ma’ani Hessari, N., Spindler, L., Troha, T., Lam, W. C., Drevenšek-Olenik, I., & Webba da Silva, M. (2014). Programmed Self-Assembly of a Quadruplex DNA Nanowire. Chemistry - A European Journal, 20(13), 3626-3630. https://doi.org/10.1002/chem.201300692