Profile of anisometropia and aniso-astigmatism in children: prevalence and association with age, ocular biometric measures and refractive status

L O'Donoghue, JF McClelland, NS Logan, AR Rudnicka, CG Owen, KJ Saunders

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose To describe the profile and associations of anisometropia and aniso-astigmatism in a population-based sample of children MethodsThe NICER (Northern Ireland Childhood Errors of Refraction) study used a stratified random cluster design to recruit a representative sample of children from schools in NI. Examinations included cycloplegic (1% cyclopentolate) autorefraction and measures of axial length, anterior chamber depth and corneal curvature. ² tests were used to assess variations in the prevalence of anisometropia and aniso-astigmatism by age-group, with logistic regression used to compare odds of anisometropia and aniso-astigmatism with refractive status (myopia, emmetropia, hyperopia). Mann Whitney U-test was used to examine inter-ocular differences in ocular biometry. ResultsData from 661 white children aged 12-13 years (50.5% male) and 389 white children aged 6-7 years (49.6% male) are presented. The prevalence of anisometropia ≥1DS did not differ statistically significantly between 6-7-year-old (8.5%, 95% CIs 3.9-13.1) and 12-13-year-old children (9.4%, 95% CIs 5.9-12.9). The prevalence of aniso-astigmatism ≥1DC did not vary statistically significantly between 6-7-year-old (7.7%, 95% CIs 4.3-11.2) and 12-13-year-old children (5.6%, 95% CIs 0.5-8.1). Anisometropia and aniso-astigmatism were more common in 12-13-year children with hyperopia ≥+2DS. Anisometropic eyes had greater axial length asymmetry than non-anisometropic eyes; aniso-astigmatic eyes were more asymmetric in axial length and corneal astigmatism than eyes without aniso-astigmatism.ConclusionsIn this population there is a high prevalence of axial anisometropia and corneal/axial aniso-astigmatism, associated with hyperopia but whether these relations are causal is unclear. Further work is required to clarify the developmental mechanism behind these associations.
LanguageEnglish
Pages602-608
JournalInvestigative Ophthalmology and Visual Science
Volume54
Issue number1
DOIs
Publication statusPublished - 11 Dec 2012

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Anisometropia
Astigmatism
Hyperopia
Cyclopentolate
Emmetropia
Biometry
Mydriatics
Northern Ireland
Myopia
Anterior Chamber
Nonparametric Statistics
Population
Age Groups
Logistic Models

Cite this

@article{870d714ae4df4ea4b21ab5a3cd528c14,
title = "Profile of anisometropia and aniso-astigmatism in children: prevalence and association with age, ocular biometric measures and refractive status",
abstract = "Purpose To describe the profile and associations of anisometropia and aniso-astigmatism in a population-based sample of children MethodsThe NICER (Northern Ireland Childhood Errors of Refraction) study used a stratified random cluster design to recruit a representative sample of children from schools in NI. Examinations included cycloplegic (1{\%} cyclopentolate) autorefraction and measures of axial length, anterior chamber depth and corneal curvature. ² tests were used to assess variations in the prevalence of anisometropia and aniso-astigmatism by age-group, with logistic regression used to compare odds of anisometropia and aniso-astigmatism with refractive status (myopia, emmetropia, hyperopia). Mann Whitney U-test was used to examine inter-ocular differences in ocular biometry. ResultsData from 661 white children aged 12-13 years (50.5{\%} male) and 389 white children aged 6-7 years (49.6{\%} male) are presented. The prevalence of anisometropia ≥1DS did not differ statistically significantly between 6-7-year-old (8.5{\%}, 95{\%} CIs 3.9-13.1) and 12-13-year-old children (9.4{\%}, 95{\%} CIs 5.9-12.9). The prevalence of aniso-astigmatism ≥1DC did not vary statistically significantly between 6-7-year-old (7.7{\%}, 95{\%} CIs 4.3-11.2) and 12-13-year-old children (5.6{\%}, 95{\%} CIs 0.5-8.1). Anisometropia and aniso-astigmatism were more common in 12-13-year children with hyperopia ≥+2DS. Anisometropic eyes had greater axial length asymmetry than non-anisometropic eyes; aniso-astigmatic eyes were more asymmetric in axial length and corneal astigmatism than eyes without aniso-astigmatism.ConclusionsIn this population there is a high prevalence of axial anisometropia and corneal/axial aniso-astigmatism, associated with hyperopia but whether these relations are causal is unclear. Further work is required to clarify the developmental mechanism behind these associations.",
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Profile of anisometropia and aniso-astigmatism in children: prevalence and association with age, ocular biometric measures and refractive status. / O'Donoghue, L; McClelland, JF; Logan, NS; Rudnicka, AR; Owen, CG; Saunders, KJ.

In: Investigative Ophthalmology and Visual Science, Vol. 54, No. 1, 11.12.2012, p. 602-608.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Profile of anisometropia and aniso-astigmatism in children: prevalence and association with age, ocular biometric measures and refractive status

AU - O'Donoghue, L

AU - McClelland, JF

AU - Logan, NS

AU - Rudnicka, AR

AU - Owen, CG

AU - Saunders, KJ

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N2 - Purpose To describe the profile and associations of anisometropia and aniso-astigmatism in a population-based sample of children MethodsThe NICER (Northern Ireland Childhood Errors of Refraction) study used a stratified random cluster design to recruit a representative sample of children from schools in NI. Examinations included cycloplegic (1% cyclopentolate) autorefraction and measures of axial length, anterior chamber depth and corneal curvature. ² tests were used to assess variations in the prevalence of anisometropia and aniso-astigmatism by age-group, with logistic regression used to compare odds of anisometropia and aniso-astigmatism with refractive status (myopia, emmetropia, hyperopia). Mann Whitney U-test was used to examine inter-ocular differences in ocular biometry. ResultsData from 661 white children aged 12-13 years (50.5% male) and 389 white children aged 6-7 years (49.6% male) are presented. The prevalence of anisometropia ≥1DS did not differ statistically significantly between 6-7-year-old (8.5%, 95% CIs 3.9-13.1) and 12-13-year-old children (9.4%, 95% CIs 5.9-12.9). The prevalence of aniso-astigmatism ≥1DC did not vary statistically significantly between 6-7-year-old (7.7%, 95% CIs 4.3-11.2) and 12-13-year-old children (5.6%, 95% CIs 0.5-8.1). Anisometropia and aniso-astigmatism were more common in 12-13-year children with hyperopia ≥+2DS. Anisometropic eyes had greater axial length asymmetry than non-anisometropic eyes; aniso-astigmatic eyes were more asymmetric in axial length and corneal astigmatism than eyes without aniso-astigmatism.ConclusionsIn this population there is a high prevalence of axial anisometropia and corneal/axial aniso-astigmatism, associated with hyperopia but whether these relations are causal is unclear. Further work is required to clarify the developmental mechanism behind these associations.

AB - Purpose To describe the profile and associations of anisometropia and aniso-astigmatism in a population-based sample of children MethodsThe NICER (Northern Ireland Childhood Errors of Refraction) study used a stratified random cluster design to recruit a representative sample of children from schools in NI. Examinations included cycloplegic (1% cyclopentolate) autorefraction and measures of axial length, anterior chamber depth and corneal curvature. ² tests were used to assess variations in the prevalence of anisometropia and aniso-astigmatism by age-group, with logistic regression used to compare odds of anisometropia and aniso-astigmatism with refractive status (myopia, emmetropia, hyperopia). Mann Whitney U-test was used to examine inter-ocular differences in ocular biometry. ResultsData from 661 white children aged 12-13 years (50.5% male) and 389 white children aged 6-7 years (49.6% male) are presented. The prevalence of anisometropia ≥1DS did not differ statistically significantly between 6-7-year-old (8.5%, 95% CIs 3.9-13.1) and 12-13-year-old children (9.4%, 95% CIs 5.9-12.9). The prevalence of aniso-astigmatism ≥1DC did not vary statistically significantly between 6-7-year-old (7.7%, 95% CIs 4.3-11.2) and 12-13-year-old children (5.6%, 95% CIs 0.5-8.1). Anisometropia and aniso-astigmatism were more common in 12-13-year children with hyperopia ≥+2DS. Anisometropic eyes had greater axial length asymmetry than non-anisometropic eyes; aniso-astigmatic eyes were more asymmetric in axial length and corneal astigmatism than eyes without aniso-astigmatism.ConclusionsIn this population there is a high prevalence of axial anisometropia and corneal/axial aniso-astigmatism, associated with hyperopia but whether these relations are causal is unclear. Further work is required to clarify the developmental mechanism behind these associations.

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