Problem-solving and spatial working memory in patients with schizophrenia and with focal frontal and temporal lobe lesions.

T M Rushe, R G Morris, E C Miotto, J D Feigenbaum, P W Woodruff, R M Murray

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    Problem-solving ability was investigated in 25 DSM-IIIR schizophrenic (SC) patients using the Tower of Hanoi (TOH) task. Their performance was compared to that of: (1) 22 patients with neurosurgical unilateral prefrontal lesions, 11 left (LF) and 10 right hemisphere (RF); (2) 38 patients with unilateral temporal lobectomies, 19 left (LT) and 19 right (RT); and (3) 44 matched control subjects. Like the RT and LF group, the schizophrenics were significantly impaired on the TOH. The deficit shown by the schizophrenic group was equivalent whether or not the problems to be solved included goal-subgoal conflicts, unlike the LF group who were impaired specifically on these problems. The nature of the SC deficit was also distinct from that of the RT group, in that the problem-solving deficit remained after controlling for the effects of spatial memory performance. This study indicates, therefore, that neither focal frontal nor temporal lobe damage sustained in adult life is a sufficient explanation for the problem-solving deficits found in patients with schizophrenia.
    LanguageEnglish
    Pages21-33
    JournalSchizophrenia Research
    Volume37
    Issue number1
    Publication statusPublished - 1999

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    Frontal Lobe
    Temporal Lobe
    Short-Term Memory
    Schizophrenia
    Aptitude
    Spatial Memory

    Cite this

    Rushe, T. M., Morris, R. G., Miotto, E. C., Feigenbaum, J. D., Woodruff, P. W., & Murray, R. M. (1999). Problem-solving and spatial working memory in patients with schizophrenia and with focal frontal and temporal lobe lesions. 37(1), 21-33.
    Rushe, T M ; Morris, R G ; Miotto, E C ; Feigenbaum, J D ; Woodruff, P W ; Murray, R M. / Problem-solving and spatial working memory in patients with schizophrenia and with focal frontal and temporal lobe lesions. 1999 ; Vol. 37, No. 1. pp. 21-33.
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    Rushe, TM, Morris, RG, Miotto, EC, Feigenbaum, JD, Woodruff, PW & Murray, RM 1999, 'Problem-solving and spatial working memory in patients with schizophrenia and with focal frontal and temporal lobe lesions.', vol. 37, no. 1, pp. 21-33.

    Problem-solving and spatial working memory in patients with schizophrenia and with focal frontal and temporal lobe lesions. / Rushe, T M; Morris, R G; Miotto, E C; Feigenbaum, J D; Woodruff, P W; Murray, R M.

    Vol. 37, No. 1, 1999, p. 21-33.

    Research output: Contribution to journalArticle

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    AU - Rushe, T M

    AU - Morris, R G

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    AU - Murray, R M

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    AB - Problem-solving ability was investigated in 25 DSM-IIIR schizophrenic (SC) patients using the Tower of Hanoi (TOH) task. Their performance was compared to that of: (1) 22 patients with neurosurgical unilateral prefrontal lesions, 11 left (LF) and 10 right hemisphere (RF); (2) 38 patients with unilateral temporal lobectomies, 19 left (LT) and 19 right (RT); and (3) 44 matched control subjects. Like the RT and LF group, the schizophrenics were significantly impaired on the TOH. The deficit shown by the schizophrenic group was equivalent whether or not the problems to be solved included goal-subgoal conflicts, unlike the LF group who were impaired specifically on these problems. The nature of the SC deficit was also distinct from that of the RT group, in that the problem-solving deficit remained after controlling for the effects of spatial memory performance. This study indicates, therefore, that neither focal frontal nor temporal lobe damage sustained in adult life is a sufficient explanation for the problem-solving deficits found in patients with schizophrenia.

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    Rushe TM, Morris RG, Miotto EC, Feigenbaum JD, Woodruff PW, Murray RM. Problem-solving and spatial working memory in patients with schizophrenia and with focal frontal and temporal lobe lesions. 1999;37(1):21-33.