Primary Structure of Neuromedin U from the Rat

J. M. Conlon, J. Domin, L. Thim, V. DiMarzo, H. R. Morris, S. R. Bloom, L. Thim, V. DiMarzo, H. R. Morris

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60 Citations (Scopus)


Abstract: The primary structure of neuromedin U from the rat ileum was established as: Tyr‐Lys‐Val‐Asn‐Glu5‐Tyr‐Gln‐Gly‐Pro‐Val10‐Ala‐Pro‐Ser‐Gly‐Gly15‐Phe‐Phe‐Leu‐Phe‐Arg20‐Pro‐Arg‐Asn‐NH2. There was no evidence for microheterogeneity. This amino acid sequence contains two deletions and nine substitutions compared with the neuromedin U‐25 from the pig. In particular, the replacement of the Arg'6‐Arg17 processing site in the porcine peptide by Gly14‐Gly15 in the rat means that a peptide corresponding to neuromedin U‐8 was not found in the rat intestine.

Original languageEnglish
Pages (from-to)988-991
Number of pages4
JournalJournal of Neurochemistry
Issue number3
Publication statusPublished (in print/issue) - Sept 1988


  • Edman degradation
  • Neuromedin U
  • Radioimmunoassay
  • Rat gastrointestinal tract


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