Primary structure of glucagon from the gut of the common dogfish (Scyliorhinus canicula)

J. Michael Conlon, Liam O'Toole, Lars Thim

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The primary structure of glucagon isolated from the intestine of the common dogfish, Scyliorhinus canicula, was established as 5 10 15 20 25 H S E G T F T S D Y S K Y M D N R R A K D F V Q W L M N T. The peptide shows four substitutions compared with human glucagon: Glu-3 for Gln, Met-14 for Leu, Asn-16 for Ser and Lys-20 for Gln. Glucagon represented the predominant molecular form of the glucagon-like immunoreactivity in the dogfish gut extracts demonstrating that the pathway of posttranslational processing of proglucagon in the gut of this fish differs markedly from the pathway in the mammalian gut.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalFEBS Letters
Volume214
Issue number1
DOIs
Publication statusPublished (in print/issue) - 6 Apr 1987

Keywords

  • (Elasmobranch)
  • Edman degradation
  • HPLC
  • Posttranslational processing
  • Radioimmunoassay

Fingerprint

Dive into the research topics of 'Primary structure of glucagon from the gut of the common dogfish (Scyliorhinus canicula)'. Together they form a unique fingerprint.

Cite this