Primary structure of glucagon from the gut of the common dogfish (Scyliorhinus canicula)

J. Michael Conlon, Liam O'Toole, Lars Thim

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20 Citations (Scopus)


The primary structure of glucagon isolated from the intestine of the common dogfish, Scyliorhinus canicula, was established as 5 10 15 20 25 H S E G T F T S D Y S K Y M D N R R A K D F V Q W L M N T. The peptide shows four substitutions compared with human glucagon: Glu-3 for Gln, Met-14 for Leu, Asn-16 for Ser and Lys-20 for Gln. Glucagon represented the predominant molecular form of the glucagon-like immunoreactivity in the dogfish gut extracts demonstrating that the pathway of posttranslational processing of proglucagon in the gut of this fish differs markedly from the pathway in the mammalian gut.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalFEBS Letters
Issue number1
Publication statusPublished (in print/issue) - 6 Apr 1987


  • (Elasmobranch)
  • Edman degradation
  • HPLC
  • Posttranslational processing
  • Radioimmunoassay


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