Primary Structure and Tissue Distribution of Guinea Pig Gastrin‐Releasing Peptide

C. Shaw; L. Thim; J. M. Conlon

doi:10.1111/j.1471-4159.1987.tb00998.x

Primary Structure and Tissue Distribution of Guinea Pig Gastrin‐Releasing Peptide

C. Shaw, L. Thim, J. M. Conlon

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The primary structure of gastrin‐releasing peptide from the guinea pig stomach has been determined by automated Edman degradation and shown to be identical to porcine gastrin‐releasing peptide. Extracts of guinea pig brain and small intestine contained both gastrin‐releasing peptide and its COOH‐terminal decapeptide (neuromedin C) but the stomach extracts contained only gastrin‐releasing peptide. Within the small intestine, highest concentrations of gastrin‐releasing peptide‐like immunoreactivity were found in extracts of the circular and longitudinal smooth muscle layers.

Original language	English
Pages (from-to)	1348-1354
Number of pages	7
Journal	Journal of Neurochemistry
Volume	49
Issue number	5
DOIs	https://doi.org/10.1111/j.1471-4159.1987.tb00998.x
Publication status	Published (in print/issue) - Nov 1987

Keywords

Edman degradation
Gastrin‐releasing peptide
Guinea pig gastrointestinal tract
Neuromedin C

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10.1111/j.1471-4159.1987.tb00998.x

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AB - The primary structure of gastrin‐releasing peptide from the guinea pig stomach has been determined by automated Edman degradation and shown to be identical to porcine gastrin‐releasing peptide. Extracts of guinea pig brain and small intestine contained both gastrin‐releasing peptide and its COOH‐terminal decapeptide (neuromedin C) but the stomach extracts contained only gastrin‐releasing peptide. Within the small intestine, highest concentrations of gastrin‐releasing peptide‐like immunoreactivity were found in extracts of the circular and longitudinal smooth muscle layers.

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KW - Gastrin‐releasing peptide

KW - Guinea pig gastrointestinal tract

KW - Neuromedin C

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JF - Journal of Neurochemistry

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ER -

Primary Structure and Tissue Distribution of Guinea Pig Gastrin‐Releasing Peptide

Abstract

Keywords

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