Precision Printing of Customized Cylindrical Capsules with Multifunctional Layers for Oral Drug Delivery

Xuefeng Li, Chunchen Zhang, Shuting Wu, Xing Chen, John Mai, Ming Wei Chang

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Advances in personalized medicine will require custom drug formulations and delivery mechanisms. Herein, we demonstrate a new type of personalized capsule comprising of printed concentric cylindrical layers with each layer having a distinctive functional drug component. Poly ϵ-caprolactone (PCL) with paracetamol (APAP) and chlorpheniramine maleate (CM), synergistic drugs commonly used to alleviate influenza symptoms, are printed as an inner layer and outer layer, respectively, via microscaled electrohydrodynamic (EHD) printing. Polyvinylpyrrolidone (PVP) nanofibers are embedded as interlayers between the two printed PCL-drug layers using electrospinning (ES) techniques. The complete concentric cylindrical capsule with a 6 mm inner diameter and 15 mm length can be swallowed for oral drug delivery. After dissolution of the PVP interlayer, the capsule separates in two, with inner and outer capsules for continuous drug dosing and targeting. Imaging was achieved using a 3T MRI system which allowed temporal observations of the targeted release through the incorporation of nanoparticles (Fe3O4). The morphology and structure, chemical composition, mechanical properties, and biocompatibility of the capsules were studied in vitro. In summary, this new type of custom printed and electrospun capsule that enabled component separation, targeted drug release may advance personalized medicine via multidrug oral delivery.

    Original languageEnglish
    Pages (from-to)39179-39191
    Number of pages13
    JournalACS Applied Materials and Interfaces
    Volume11
    Issue number42
    Early online date1 Oct 2019
    DOIs
    Publication statusPublished - 23 Oct 2019

    Keywords

    • capsule separation
    • composite capsules
    • controlled release
    • micro printing
    • multicomponent drugs

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