Precision medicine to manage chronic immune-related conditions

David Gibson, Philip Egan, Guangran Guo, Catriona Kelly, Paula McClean, V. E. McGilligan, Roisin Mc Allister, Kyle Matchett, Chloe Martin, EK Murray, Coral Lapsley, Taranjit Singh Rai, AJ Bjourson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The dysregulated immune system represents a major target for improving health outcomes in a range of chronic conditions. This chapter describes key changes in the immune system as we age and showcases its dysregulation across five chronic conditions including diabetes, cardiovascular disease, and cancer, highlighting dysregulated key immune system pathways and resultant inflammatory sequelae. Precision medicine aims to subdivide patients into different groups who will respond to specific treatments and could offer a novel way of addressing the complexity of immune system involvement in these conditions. The potential for precision medicine-led therapeutic strategies is discussed for each condition and considered in the context of
multimorbidity.
Original languageEnglish
Title of host publicationTranslational Autoimmunity
Subtitle of host publicationTreatment of Autoimmune Diseases
EditorsNima Rizaei
PublisherElsevier
Chapter14
Pages295-318
Number of pages24
Volume2
Edition1st
ISBN (Electronic)9780128243909
ISBN (Print)9780128243909
DOIs
Publication statusPublished - 17 Jan 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.

Keywords

  • autoimmune disease
  • Precision medicine
  • Immunology
  • therapeutic interventions
  • Diabetes mellitus
  • Genomics
  • Rheumatoid arthritis
  • Cardiovascular disease
  • Depression
  • Immunosenescence
  • Cancer
  • Multimorbidity

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