Precision medicine to manage chronic immune-related conditions

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


The dysregulated immune system represents a major target for improving health outcomes in a range of chronic conditions. This chapter describes key changes in the immune system as we age and showcases its dysregulation across five chronic conditions including diabetes, cardiovascular disease, and cancer, highlighting dysregulated key immune system pathways and resultant inflammatory sequelae. Precision medicine aims to subdivide patients into different groups who will respond to specific treatments and could offer a novel way of addressing the complexity of immune system involvement in these conditions. The potential for precision medicine-led therapeutic strategies is discussed for each condition and considered in the context of
Original languageEnglish
Title of host publicationTranslational Autoimmunity
Subtitle of host publicationTreatment of Autoimmune Diseases
EditorsNima Rizaei
Number of pages24
ISBN (Electronic)9780128243909
ISBN (Print)9780128243909
Publication statusPublished (in print/issue) - 17 Jan 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.

Funding Information:
The NI Centre for Stratified Medicine has been funded by a grant to AB under the EU Regional Development Fund and EU Sustainable Competitiveness Programme for NI & the NI Public Health Agency. The authors also wish to acknowledge the award of Ph.D. fellowships from the Department for Economy and support from Northern Ireland Rheumatism Trust, Versus Arthritis, Invest Northern Ireland, Little Princess Trust, Cystic Fibrosis Trust, Western Health & Social Care Trust, and the Research and Development Office of the Public Health Authority.

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.


  • autoimmune disease
  • Precision medicine
  • Immunology
  • therapeutic interventions
  • Diabetes mellitus
  • Genomics
  • Rheumatoid arthritis
  • Cardiovascular disease
  • Depression
  • Immunosenescence
  • Cancer
  • Multimorbidity


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