Precision medicine to manage chronic immune-related conditions

David Gibson; Philip Egan; Guangran Guo; Catriona Kelly; Paula McClean; V. E. McGilligan; Roisin Mc Allister; Kyle Matchett; Chloe Martin; EK Murray; Coral Lapsley; Taranjit Singh Rai; AJ Bjourson

doi:10.1016/B978-0-12-824390-9.00009-8

Precision medicine to manage chronic immune-related conditions

David Gibson, Philip Egan, Guangran Guo, Catriona Kelly, Paula McClean, V. E. McGilligan, Roisin Mc Allister, Kyle Matchett, Chloe Martin, EK Murray, Coral Lapsley, Taranjit Singh Rai, AJ Bjourson

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

The dysregulated immune system represents a major target for improving health outcomes in a range of chronic conditions. This chapter describes key changes in the immune system as we age and showcases its dysregulation across five chronic conditions including diabetes, cardiovascular disease, and cancer, highlighting dysregulated key immune system pathways and resultant inflammatory sequelae. Precision medicine aims to subdivide patients into different groups who will respond to specific treatments and could offer a novel way of addressing the complexity of immune system involvement in these conditions. The potential for precision medicine-led therapeutic strategies is discussed for each condition and considered in the context of
multimorbidity.

Original language	English
Title of host publication	Translational Autoimmunity
Subtitle of host publication	Treatment of Autoimmune Diseases
Editors	Nima Rizaei
Publisher	Elsevier
Chapter	14
Pages	295-318
Number of pages	24
Volume	2
Edition	1st
ISBN (Electronic)	9780128243909
ISBN (Print)	9780128243909
DOIs	https://doi.org/10.1016/B978-0-12-824390-9.00009-8
Publication status	Published (in print/issue) - 17 Jan 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.

Funding Information:
The NI Centre for Stratified Medicine has been funded by a grant to AB under the EU Regional Development Fund and EU Sustainable Competitiveness Programme for NI & the NI Public Health Agency. The authors also wish to acknowledge the award of Ph.D. fellowships from the Department for Economy and support from Northern Ireland Rheumatism Trust, Versus Arthritis, Invest Northern Ireland, Little Princess Trust, Cystic Fibrosis Trust, Western Health & Social Care Trust, and the Research and Development Office of the Public Health Authority.

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.

Keywords

autoimmune disease
Precision medicine
Immunology
therapeutic interventions
Diabetes mellitus
Genomics
Rheumatoid arthritis
Cardiovascular disease
Depression
Immunosenescence
Cancer
Multimorbidity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-824390-9.00009-8

Cite this

Gibson, D., Egan, P., Guo, G., Kelly, C., McClean, P., McGilligan, V. E., Mc Allister, R., Matchett, K., Martin, C., Murray, EK., Lapsley, C., Rai, T. S., & Bjourson, AJ. (2022). Precision medicine to manage chronic immune-related conditions. In N. Rizaei (Ed.), Translational Autoimmunity: Treatment of Autoimmune Diseases (1st ed., Vol. 2, pp. 295-318). Elsevier. https://doi.org/10.1016/B978-0-12-824390-9.00009-8

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abstract = "The dysregulated immune system represents a major target for improving health outcomes in a range of chronic conditions. This chapter describes key changes in the immune system as we age and showcases its dysregulation across five chronic conditions including diabetes, cardiovascular disease, and cancer, highlighting dysregulated key immune system pathways and resultant inflammatory sequelae. Precision medicine aims to subdivide patients into different groups who will respond to specific treatments and could offer a novel way of addressing the complexity of immune system involvement in these conditions. The potential for precision medicine-led therapeutic strategies is discussed for each condition and considered in the context ofmultimorbidity.",

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Gibson, D, Egan, P, Guo, G, Kelly, C , McClean, P , McGilligan, VE , Mc Allister, R , Matchett, K, Martin, C, Murray, EK, Lapsley, C, Rai, TS & Bjourson, AJ 2022, Precision medicine to manage chronic immune-related conditions. in N Rizaei (ed.), Translational Autoimmunity: Treatment of Autoimmune Diseases. 1st edn, vol. 2, Elsevier, pp. 295-318. https://doi.org/10.1016/B978-0-12-824390-9.00009-8

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AU - Martin, Chloe

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AU - Lapsley, Coral

AU - Rai, Taranjit Singh

AU - Bjourson, AJ

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N2 - The dysregulated immune system represents a major target for improving health outcomes in a range of chronic conditions. This chapter describes key changes in the immune system as we age and showcases its dysregulation across five chronic conditions including diabetes, cardiovascular disease, and cancer, highlighting dysregulated key immune system pathways and resultant inflammatory sequelae. Precision medicine aims to subdivide patients into different groups who will respond to specific treatments and could offer a novel way of addressing the complexity of immune system involvement in these conditions. The potential for precision medicine-led therapeutic strategies is discussed for each condition and considered in the context ofmultimorbidity.

AB - The dysregulated immune system represents a major target for improving health outcomes in a range of chronic conditions. This chapter describes key changes in the immune system as we age and showcases its dysregulation across five chronic conditions including diabetes, cardiovascular disease, and cancer, highlighting dysregulated key immune system pathways and resultant inflammatory sequelae. Precision medicine aims to subdivide patients into different groups who will respond to specific treatments and could offer a novel way of addressing the complexity of immune system involvement in these conditions. The potential for precision medicine-led therapeutic strategies is discussed for each condition and considered in the context ofmultimorbidity.

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KW - therapeutic interventions

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KW - Cardiovascular disease

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M3 - Chapter

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VL - 2

SP - 295

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BT - Translational Autoimmunity

A2 - Rizaei, Nima

PB - Elsevier

ER -

Precision medicine to manage chronic immune-related conditions

Abstract

Bibliographical note

Keywords

UN SDGs

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